{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:33:56Z","timestamp":1790624036297,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T00:00:00Z","timestamp":1364428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2013,5]]},"abstract":"\n Sodium butyrate (\n BU<\/jats:styled-content>\n ) is a molecule that acts as a histone deacetylase inhibitor. As compared with its well\u2010known antineoplastic\/antiproliferative effects, little is known about\n BU<\/jats:styled-content>\n action on vascular cell dynamics. An imbalance of proliferation and migration in pulmonary arterial smooth muscle cells (\n PASMC<\/jats:styled-content>\n s) is essential in the onset and progression of pulmonary arterial hypertension (\n PAH<\/jats:styled-content>\n ), a disease that is characterized by vascular lung derangement and that frequently has an unfavorable outcome. Here, we show that, in\n PASMC<\/jats:styled-content>\n s of\n PAH<\/jats:styled-content>\n rats,\n BU<\/jats:styled-content>\n counteracted platelet\u2010derived growth factor (\n PDGF<\/jats:styled-content>\n )\u2010induced\n K<\/jats:styled-content>\n i67 expression, and arrested the cell cycle, mainly at\n G<\/jats:styled-content>\n 0<\/jats:sub>\n \/\n G<\/jats:styled-content>\n 1<\/jats:sub>\n .\n BU<\/jats:styled-content>\n decreased proliferating cell nuclear antigen, c\u2010Myc and cyclin\u00a0\n D<\/jats:styled-content>\n 1 transcription and protein expression, while increasing p21 expression.\n BU<\/jats:styled-content>\n reduced the transcription of\n PDGF<\/jats:styled-content>\n receptor\u2010\u03b2, and that of\n E<\/jats:styled-content>\n dnra and\n E<\/jats:styled-content>\n dnrb, two major receptors in\n PAH<\/jats:styled-content>\n progression. Wound healing, migration and pulmonary artery ring assays indicated that\n BU<\/jats:styled-content>\n inhibited\n PDGF<\/jats:styled-content>\n \u2010induced\n PASMC<\/jats:styled-content>\n migration.\n BU<\/jats:styled-content>\n strongly inhibited\n PDGF<\/jats:styled-content>\n \u2010induced\n A<\/jats:styled-content>\n kt phosphorylation, an effect reversed by the phosphatase inhibitor calyculin\u00a0A.\n BU<\/jats:styled-content>\n \u2010treated cells showed a remarkable increase in acetylated\n A<\/jats:styled-content>\n kt, indicating an inverse relationship between the levels of acetylated\n A<\/jats:styled-content>\n kt and phospho\u2010\n A<\/jats:styled-content>\n kt. These findings may provide novel perspectives on the use of histone deacetylase inhibitors in\n PAH<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/febs.12227","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T01:52:52Z","timestamp":1362621172000},"page":"2042-2055","source":"Crossref","is-referenced-by-count":49,"title":["Sodium butyrate inhibits platelet\u2010derived growth factor\u2010induced proliferation and migration in pulmonary artery smooth muscle cells through\n A<\/scp>\n kt inhibition"],"prefix":"10.1111","volume":"280","author":[{"given":"Silvia","family":"Cantoni","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and Biosystems Bologna Italy"},{"name":"Specialized Experimental and Diagnostic Medicine University of Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Galletti","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and Biosystems Bologna Italy"},{"name":"Specialized Experimental and Diagnostic Medicine University of Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Zambelli","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and Biosystems Bologna Italy"},{"name":"Societ\u00e0 Italiana Studi Medicina della Riproduzione (S.I.S.Me.R.) Reproductive Medicine Unit Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Valente","sequence":"additional","affiliation":[{"name":"Specialized Experimental and Diagnostic Medicine University of Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ponti","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and Biosystems Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Tassinari","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and Biosystems Bologna Italy"},{"name":"Specialized Experimental and Diagnostic Medicine University of Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianandrea","family":"Pasquinelli","sequence":"additional","affiliation":[{"name":"Specialized Experimental and Diagnostic Medicine University of Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazzareno","family":"Gali\u00e8","sequence":"additional","affiliation":[{"name":"Specialized Experimental and Diagnostic Medicine University of Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Ventura","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and Biosystems Bologna Italy"},{"name":"Specialized Experimental and Diagnostic Medicine University of Bologna 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