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Three genes give rise to three main isoforms in mammalian cells. They each function in different endocytic and vesicle trafficking pathways and provide critical links between the cytoskeletal network in different cellular processes, such as neuronal morphogenesis and cell migration. The membrane remodelling activity of syndapin via its F\u2010<jats:styled-content style=\"fixed-case\">BAR<\/jats:styled-content> domain and its interaction partners, such as dynamin and neural Wiskott\u2013Aldrich syndrome protein binding to its Src\u2010homology 3 domain, are important with respect to its function. Its various partner proteins provide insights into its mechanism of action, as well as its differential roles in these cellular processes. 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