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The presence of several chromatin related modules such as plant homeodomain (<jats:styled-content style=\"fixed-case\">PHD<\/jats:styled-content>), bromodomain and <jats:styled-content style=\"fixed-case\">SAND<\/jats:styled-content> domain suggests a role in chromatin\u2010mediated regulation of gene expression; however, its real function is still elusive. Herein we present the solution structure of <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>p140\u2010<jats:styled-content style=\"fixed-case\">PHD<\/jats:styled-content> finger and investigate its role as epigenetic reader <jats:italic>in\u00a0vitro<\/jats:italic>. Sp140\u2010<jats:styled-content style=\"fixed-case\">PHD<\/jats:styled-content> presents an atypical <jats:styled-content style=\"fixed-case\">PHD<\/jats:styled-content> finger fold which does not bind to histone <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>3 tails but is recognized by peptidylprolyl isomerase <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>in1. Pin1 specifically binds to a phosphopeptide corresponding to the <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>3 loop of <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>p140\u2010<jats:styled-content style=\"fixed-case\">PHD<\/jats:styled-content> and catalyzes <jats:italic>cis\u2013trans<\/jats:italic> isomerization of a <jats:sub>p<\/jats:sub><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>hr\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ro bond. Moreover co\u2010immunoprecipitation experiments demonstrate <jats:styled-content style=\"fixed-case\">FLAG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>p140 interaction with endogenous <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>in1 <jats:italic>in\u00a0vivo<\/jats:italic>. Overall these data include <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>p140 in the list of the increasing number of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>in1 binders and expand the regulatory potential of <jats:styled-content style=\"fixed-case\">PHD<\/jats:styled-content> fingers as versatile structural platforms for diversified interactions.<\/jats:p>","DOI":"10.1111\/febs.12588","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T13:58:28Z","timestamp":1383141508000},"page":"216-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Structure of human <scp>S<\/scp>p140 <scp>PHD<\/scp> finger: an atypical fold interacting with <scp>P<\/scp>in1"],"prefix":"10.1111","volume":"281","author":[{"given":"Chiara","family":"Zucchelli","sequence":"first","affiliation":[{"name":"Dulbecco Telethon Institute c\/o Biomolecular NMR Laboratory S. 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