{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:41:56Z","timestamp":1788871316913,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T00:00:00Z","timestamp":1412640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"crossref","award":["14172MFDS974"],"award-info":[{"award-number":["14172MFDS974"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>\n                    X\u2010box binding protein\u00a01 (\n                    <jats:styled-content style=\"fixed-case\">XBP<\/jats:styled-content>\n                    1), a transcription factor of the unfolded protein response, plays various roles in many biological processes. We examined its pro\u2010adipogenic activity and target genes during adipogenic differentiation in wild\u2010type and genetically modified 3T3\u2010L1 cells. Signalling pathways that contribute to\n                    <jats:italic>Xbp1<\/jats:italic>\n                    m\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    splicing, and the correlation of the transcriptionally active XBP1 isoform (XBP1s) level with body mass index and the level of peroxisome proliferator\u2010activated receptor\u00a0\u03b32 (PPAR\u03b32) in human adipose tissues were also examined. The m\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    and nuclear protein expression levels of XBP1s increased immediately following hormonal induction of adipogenesis, reaching a peak at 6\u00a0h. Results from c\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    microarray and gene expression analyses using genetically modified cells indicated that PPAR\u03b32 was a principal target of XBP1s. The XBP1s\u2010specific binding motif, which is distinct from the\n                    <jats:styled-content style=\"fixed-case\">CCAAT<\/jats:styled-content>\n                    \/enhancer\u2010binding protein\u00a0\u03b1 binding site, was identified in the PPAR\u03b32 promoter by site\u2010directed mutagenesis. Fetal bovine serum, insulin, 3\u2010isobutyl\u20101\u2010methylxanthine and dexamethasone contributed independently to\n                    <jats:italic>Xbp1<\/jats:italic>\n                    m\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    splicing. In human subcutaneous adipose tissues, the levels of both\n                    <jats:italic>Xbp1s<\/jats:italic>\n                    and\n                    <jats:italic>Ppar<\/jats:italic>\n                    \u03b3\n                    <jats:italic>2<\/jats:italic>\n                    m\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    increased proportionally with body mass index, and there was a significant positive correlation between the two genes. These data suggest for the first time that positive regulation of PPAR\u03b32 is a principal mechanism of XBP1s\u2010mediated adipogenesis in 3T3\u2010L1 cells.\n                  <\/jats:p>","DOI":"10.1111\/febs.13052","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T11:49:01Z","timestamp":1410781741000},"page":"5132-5146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["X\u2010box binding protein\u00a01 is a novel key regulator of peroxisome proliferator\u2010activated receptor\u00a0\u03b32"],"prefix":"10.1111","volume":"281","author":[{"given":"Yoon Mi","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Biochemistry College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Nam","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry College 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