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In this study, we investigated the effect of quercetin (Qu) pretreatment on the potentiation of cDDP in ovarian cancer. We found that Qu pretreatment significantly enhanced cDDP cytotoxicity in an ovarian cancer cell line and primary cancer cells. In addition, we demonstrated that Qu elicited obvious endoplasmic reticulum stress (<jats:styled-content style=\"fixed-case\">ERS<\/jats:styled-content>) and activated all three branches of <jats:styled-content style=\"fixed-case\">ERS<\/jats:styled-content> in ovarian cancer. Specific inhibitors of each <jats:styled-content style=\"fixed-case\">ERS<\/jats:styled-content> pathway, as well as the general <jats:styled-content style=\"fixed-case\">ERS<\/jats:styled-content> stabilizer tauroursodeoxycholic acid, notably diminished such enhancing effects. Furthermore, Qu notably suppressed <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3 phosphorylation, leading to downregulation of the <jats:italic><jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>\u20102<\/jats:italic> gene downstream of <jats:italic><jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3<\/jats:italic>. Moreover, blocking <jats:styled-content style=\"fixed-case\">ERS<\/jats:styled-content> restored the protein levels of phosphorylated <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3 as well as <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>\u20102 expression, thus abolishing the chemosensitization potency of Qu; these results revealed that Qu affected the <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3 pathway to enhance cDDP cytotoxicity, and this effect involved <jats:styled-content style=\"fixed-case\">ERS<\/jats:styled-content> signaling. In a xenograft mouse model of ovarian cancer, Qu enhanced the antitumor effect of cDDP. Tumors from mice treated with cDDP in combination with Qu pretreatment had repressed <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3 phosphorylation, lower <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>\u20102 and higher apoptosis levels compared with those from the other groups. Meanwhile, Qu markedly reduced the elevation of blood creatinine during cDDP intervention. These data indicate that Qu pretreatment potentiates the antitumor effects of cDDP in ovarian cancer while protecting the kidneys against damage. Therefore the strategy of Qu pretreatment may be beneficial in enhancing the therapeutic efficacy of cDDP against ovarian cancer.<\/jats:p>","DOI":"10.1111\/febs.13206","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T14:13:59Z","timestamp":1421936039000},"page":"1111-1125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["<i>Retracted:<\/i> Quercetin induces endoplasmic reticulum stress to enhance c<scp>DDP<\/scp> cytotoxicity in ovarian cancer: involvement of <scp>STAT<\/scp>3 signaling"],"prefix":"10.1111","volume":"282","author":[{"given":"Zongyuan","family":"Yang","sequence":"first","affiliation":[{"name":"Cancer Biology Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Biology Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"},{"name":"Department of Medicinal Chemistry School of Pharmacy Hubei University of Chinese Medicine Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Gynecology Zhongnan Hospital Medical College of Wuhan University China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Gong","sequence":"additional","affiliation":[{"name":"Cancer Biology Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyang","family":"Sun","sequence":"additional","affiliation":[{"name":"Cancer Biology Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Cancer Biology Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wei","sequence":"additional","affiliation":[{"name":"Cancer Biology Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Biology Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglei","family":"Gao","sequence":"additional","affiliation":[{"name":"Cancer Biology Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Ma","sequence":"additional","affiliation":[{"name":"Cancer Biology Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Cancer Biology Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(06)60033-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(02)00161-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.4.6.889"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200400427"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/4.suppl_4.S35"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072748"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2012.05.020"},{"key":"e_1_2_8_9_1","first-page":"172","article-title":"Quercetin. 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