{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:06:05Z","timestamp":1791644765314,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T00:00:00Z","timestamp":1428710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"crossref","award":["BS2014YY048"],"award-info":[{"award-number":["BS2014YY048"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"crossref","award":["ZR2011CM022"],"award-info":[{"award-number":["ZR2011CM022"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>Rebamipide is a routine drug for the treatment of gastritis in a clinical setting. Recently, it has been shown to protect against various inflammatory diseases, and has provided a potential therapy for these diseases. However, whether rebamipide has a role in dermatitis remains to be elucidated. Here, we found that rebamipide alleviated the inflammatory reaction induced by tumor necrosis factor\u2010\u03b1 in <jats:styled-content style=\"fixed-case\">RAW<\/jats:styled-content>264.7, a stable macrophage cell line. Furthermore, rebamipide treatment repressed activation of nuclear factor\u2010kappaB signaling, a well\u2010established inflammatory signaling pathway. Moreover, an oxazolone\u2010induced dermatitis mouse model was established to investigate the role of rebamipide <jats:italic>in\u00a0vivo<\/jats:italic>. PBS control group exhibited typical skin inflammation, whereas treatment with rebamipide remarkably attenuated a dermatitis phenotype in this mouse model. The protective role of rebamipide in dermatitis <jats:italic>in\u00a0vivo<\/jats:italic> was probably due to its inhibition of nuclear factor\u2010kappaB signaling. Collectively, rebamipide may represent a promising molecular target for the prevention and treatment of inflammatory skin diseases.<\/jats:p>","DOI":"10.1111\/febs.13278","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T08:57:41Z","timestamp":1427446661000},"page":"2317-2326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Rebamipide suppresses <scp>TNF<\/scp>\u2010\u03b1 mediated inflammation <i>in\u00a0vitro<\/i> and attenuates the severity of dermatitis in mice"],"prefix":"10.1111","volume":"282","author":[{"given":"Weiwei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology Qilu Hospital Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Qilu Hospital Shandong University Jinan 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