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However, little is known about the regulation of <jats:styled-content style=\"fixed-case\">RPTP<\/jats:styled-content>\u03b1 expression. mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s target multiple genes and play important roles in many cancer processes. Here, we identified a mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>, miR\u2010218 that binds directly to the 3\u2032\u2010<jats:styled-content style=\"fixed-case\">UTR<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">RPTP<\/jats:styled-content>\u03b1. Ectopic overexpression of miR\u2010218 decreased <jats:styled-content style=\"fixed-case\">RPTP<\/jats:styled-content>\u03b1 protein leading to decreased dephosphorylation of c\u2010Src and decreased tumour growth <jats:italic>in\u00a0vitro<\/jats:italic> and <jats:italic>in\u00a0vivo<\/jats:italic>. A feedback loop between c\u2010Src and miR\u2010218 was revealed where c\u2010Src inhibits transcription of <jats:italic><jats:styled-content style=\"fixed-case\">SLIT<\/jats:styled-content>2<\/jats:italic>, which intronically hosts miR\u2010218. These results show a novel regulatory pathway for <jats:styled-content style=\"fixed-case\">RPTP<\/jats:styled-content>\u03b1\u2013c\u2010Src signalling.<\/jats:p>","DOI":"10.1111\/febs.13314","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T07:39:44Z","timestamp":1430725184000},"page":"2722-2734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Regulation of <scp>RPTP<\/scp>\u03b1\u2013c\u2010Src signalling pathway by miR\u2010218"],"prefix":"10.1111","volume":"282","author":[{"given":"Xueping","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Cell Biology Shanghai Key Laboratory of Tumour Microenvironment and Inflammation Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and 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