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Research has shown that oxidative stress plays a central role in the pathological process of central presbycusis. Thioredoxin\u00a02 (Trx2), one member of thioredoxin family, plays a key role in regulating the homeostasis of cellular reactive oxygen species and anti\u2010apoptosis. The purpose of this study was to explore the association between Trx2 and the phenotype of central presbycusis using a mimetic aging animal model induced by long\u2010term exposure to <jats:sc>d<\/jats:sc>\u2010galactose (<jats:sc>d<\/jats:sc>\u2010Gal). We also explored changes in thioredoxin\u2010interacting protein (<jats:styled-content style=\"fixed-case\">TXNIP<\/jats:styled-content>), apoptosis signal regulating kinase\u00a01 (<jats:styled-content style=\"fixed-case\">ASK<\/jats:styled-content>1) and phosphorylated <jats:styled-content style=\"fixed-case\">ASK<\/jats:styled-content>1 (p\u2010<jats:styled-content style=\"fixed-case\">ASK<\/jats:styled-content>1) expression, as well as the Trx2\u2013<jats:styled-content style=\"fixed-case\">TXNIP<\/jats:styled-content>\/Trx2\u2013<jats:styled-content style=\"fixed-case\">ASK<\/jats:styled-content>1 binding complex in the auditory cortex of mimetic aging rats. Our results demonstrate that, compared with control groups, the levels of Trx2 and Trx2\u2013<jats:styled-content style=\"fixed-case\">ASK<\/jats:styled-content>1 binding complex were significantly reduced, whereas <jats:styled-content style=\"fixed-case\">TXNIP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ASK<\/jats:styled-content>1 p\u2010<jats:styled-content style=\"fixed-case\">ASK<\/jats:styled-content>1 expression, and Trx2\u2013<jats:styled-content style=\"fixed-case\">TXNIP<\/jats:styled-content> binding complex were significantly increased in the auditory cortex of the mimetic aging groups. Our results indicated that changes in Trx2 and the <jats:styled-content style=\"fixed-case\">TXNIP<\/jats:styled-content>\u2013Trx2\u2013<jats:styled-content style=\"fixed-case\">ASK<\/jats:styled-content>1 signal pathway may participate in the pathogenesis of central presbycusis.<\/jats:p>","DOI":"10.1111\/febs.13324","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T15:27:30Z","timestamp":1432222050000},"page":"2758-2774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Age\u2010related changes in mitochondrial antioxidant enzyme Trx2 and <scp>TXNIP<\/scp>\u2013Trx2\u2013<scp>ASK<\/scp>1 signal pathways in the auditory cortex of a mimetic aging rat model: changes to Trx2 in the auditory cortex"],"prefix":"10.1111","volume":"282","author":[{"given":"Hai\u2010Ying","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Huazhong University of 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