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A unified clinical rating scale for the juvenile form of <jats:styled-content style=\"fixed-case\">NCL<\/jats:styled-content> has been developed, although it has not been validated in other subtypes and does not give a true measure of the pathophysiological changes occurring during disease progression. In the present study, we have identified candidate biomarkers in blood plasma of <jats:styled-content style=\"fixed-case\">NCL<\/jats:styled-content> disease using multiple proteomic approaches, with the aim of developing a panel of biomarkers that could serve as a metric for therapeutic response. Candidate biomarkers were identified as proteins with levels that significantly differed between patients and controls in both sample sets. The seven candidates identified have previously been associated with neurodegenerative and inflammatory diseases. 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