{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:13:19Z","timestamp":1787062399178,"version":"build-2736575974"},"reference-count":76,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000861","name":"Sparks","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008163","name":"A-T Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008163","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008180","name":"Action for A-T","doi-asserted-by":"publisher","award":["14SAP01"],"award-info":[{"award-number":["14SAP01"]}],"id":[{"id":"10.13039\/501100008180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>\n                    Ataxia telangiectasia (A\u2010T) is a rare incurable neurodegenerative disease caused by biallelic mutations in the gene for ataxia\u2010telangiectasia mutated (\n                    <jats:styled-content style=\"fixed-case\">ATM<\/jats:styled-content>\n                    ). The lack of a functional\n                    <jats:styled-content style=\"fixed-case\">ATM<\/jats:styled-content>\n                    kinase leads to a pleiotropic phenotype, and oxidative stress is considered to have a crucial role in the complex physiopathology. Recently, steroids have been shown to reduce the neurological symptoms of the disease, although the molecular mechanism of this effect is largely unknown. In the present study, we have demonstrated that dexamethasone treatment of A\u2010T lymphoblastoid cells increases the content of two of the most abundant antioxidants [glutathione (\n                    <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>\n                    ) and\n                    <jats:styled-content style=\"fixed-case\">NADPH<\/jats:styled-content>\n                    ] by up to 30%. Dexamethasone promoted the nuclear accumulation of the transcription factor nuclear factor (erythroid\u2010derived 2)\u2010like 2 to drive expression of antioxidant pathways involved in\n                    <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>\n                    synthesis and\n                    <jats:styled-content style=\"fixed-case\">NADPH<\/jats:styled-content>\n                    production. The latter effect was via glucose 6\u2010phosphate dehydrogenase activation, as confirmed by increased enzyme activity and enhancement of the pentose phosphate pathway rate. This evidence indicates that glucocorticoids are able to potentiate antioxidant defenses to counteract oxidative stress in ataxia telangiectasia, and also reveals an unexpected role for dexamethasone in redox homeostasis and cellular antioxidant activity.\n                  <\/jats:p>","DOI":"10.1111\/febs.13901","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T13:06:59Z","timestamp":1474031219000},"page":"3962-3978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Dexamethasone improves redox state in ataxia telangiectasia cells by promoting an NRF2\u2010mediated antioxidant response"],"prefix":"10.1111","volume":"283","author":[{"given":"Sara","family":"Biagiotti","sequence":"first","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino \u2018Carlo Bo\u2019 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Menotta","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino \u2018Carlo Bo\u2019 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Orazi","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino \u2018Carlo Bo\u2019 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Spapperi","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino \u2018Carlo Bo\u2019 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Brundu","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino \u2018Carlo Bo\u2019 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Fraternale","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino \u2018Carlo Bo\u2019 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino \u2018Carlo Bo\u2019 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigia","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino \u2018Carlo Bo\u2019 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Chessa","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine University \u2018La Sapienza\u2019 Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Magnani","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences University of Urbino \u2018Carlo Bo\u2019 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.914401"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2004.04.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.05.013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/2319-4170.125655"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201207063"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3546"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.330"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2011.10.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192912"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02989"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060614-034335"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111598200"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3230"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.01.027"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913860107"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-456897"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.125"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-373639"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.19693"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm166"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-36-11453.2003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2012.203"},{"key":"e_1_2_9_24_1","first-page":"1849","article-title":"Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm\u2010deficient mice","volume":"61","author":"Kamsler A","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700354"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1179\/135100003125001206"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1517\/21678707.2014.947264"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2010.492088"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2013.02.013"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02060.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03203.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.10.1479"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-9-5"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2012.06.002"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02600.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25126"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000098"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02597.x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12024"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.344473"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2013-7"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22925"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553008714551461"},{"key":"e_1_2_9_44_1","first-page":"5374","article-title":"Re: Impaired glutathione biosynthesis in cultured ataxia\u2010telangiectasia cells","volume":"48","author":"Dean SW","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.03.013"},{"key":"e_1_2_9_46_1","first-page":"4576","article-title":"Imparied glutathione biosynthesis in cultured human ataxia\u2010telangiectasia cells","volume":"47","author":"Meredith MJ","year":"1987","journal-title":"Cancer Res"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.02.008"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.10146"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.48.34277"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-7864(01)00007-6"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.07.028"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2008.04.011"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.05.005"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)66953-X"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.4161\/15384101.2014.950538"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.8.2.8119488"},{"key":"e_1_2_9_57_1","first-page":"465","article-title":"Effects of dexamethasone on ischemia reperfusion injury following Pringle maneuver","volume":"58","author":"Karaman K","year":"2011","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1350213"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4002"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1042\/AN20120002"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.08.011"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2015.11.003"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(02)00078-4"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106798200"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1672"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704442200"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057866"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2009.02.001"},{"key":"e_1_2_9_69_1","first-page":"131","volume-title":"Red Cell Metabolism. A Manual of Biochemical Methods","author":"Beutler E","year":"1984"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(92)90008-H"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_2_9_72_1","first-page":"68","volume-title":"Red Cell Metabolism. A Manual of Biochemical Methods","author":"Beutler E","year":"1984"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0550400"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417290112"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01799449"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(85)90405-1"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90150-3"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ffebs.13901","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.13901","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.13901","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.13901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T23:56:22Z","timestamp":1696290982000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.13901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,12]]},"references-count":76,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/febs.13901"],"URL":"https:\/\/doi.org\/10.1111\/febs.13901","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,12]]},"assertion":[{"value":"2016-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}