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This review discusses the state\u2010of\u2010the\u2010art knowledge of the enigmatic role played by <jats:styled-content style=\"fixed-case\">RUNX<\/jats:styled-content>1 in female\u2010related cancers of the breast, the uterus and the ovary. The weight of evidence accumulated so far is indicative of a very context\u2010dependent role, as either an oncogene or a tumour suppressor. This is corroborated by high\u2010throughput sequencing endeavours which report different genetic alterations affecting the gene, including amplification, deep deletion and mutations. Herein, we attempt to dissect that contextual role by firstly giving an overview of what is currently known about <jats:styled-content style=\"fixed-case\">RUNX<\/jats:styled-content>1 function in these specific tumour types, and secondly by delving into connections between this transcription factor and the physiology of these female tissues. In doing so, <jats:italic><jats:styled-content style=\"fixed-case\">RUNX<\/jats:styled-content>1<\/jats:italic> emerges not only as a gene involved in female sex development but also as a crucial mediator of female hormone signalling. In view of <jats:italic><jats:styled-content style=\"fixed-case\">RUNX<\/jats:styled-content>1<\/jats:italic> now being listed as a driver gene, we believe that greater knowledge of the mechanisms underlying its functional dualism in epithelial cancers is worthy of further investigation.<\/jats:p>","DOI":"10.1111\/febs.14059","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T11:34:40Z","timestamp":1489750480000},"page":"2345-2362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The enigmatic role of <scp>RUNX<\/scp>1 in female\u2010related cancers \u2013 current knowledge &amp; future perspectives"],"prefix":"10.1111","volume":"284","author":[{"given":"Alessandra I.","family":"Riggio","sequence":"first","affiliation":[{"name":"Cancer Research UK Beatson Institute Bearsden Glasgow 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