{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:35:59Z","timestamp":1792704959312,"version":"4.5.0"},"reference-count":102,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>\n                    Artemisinin\u2010based combination therapy (\n                    <jats:styled-content style=\"fixed-case\">ACT<\/jats:styled-content>\n                    ) has been adopted as a strategy to mitigate multidrug resistance to antimalarial monotherapies.\n                    <jats:styled-content style=\"fixed-case\">ACT<\/jats:styled-content>\n                    combines the rapid and effective but rather short plasma half\u2010life antimalarial action of an artemisinin derivative with a longer acting partner drug. Although the exact mechanisms of action of artemisinins are not well understood, several studies have proposed multiple cellular targets of artemisinins with involvement of reactive oxygen species (\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    ). Most of the currently used\n                    <jats:styled-content style=\"fixed-case\">ACT<\/jats:styled-content>\n                    partner drugs are also known to involve\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    production in their mechanisms of action. This review gives a brief account of the oxidative stress and redox systems in malaria and discusses the context of antimalarial effectiveness of different\n                    <jats:styled-content style=\"fixed-case\">ACT<\/jats:styled-content>\n                    s compared with monotherapies of the partner drugs. A final account on the Pros and Cons of\n                    <jats:styled-content style=\"fixed-case\">ACT<\/jats:styled-content>\n                    as a strategy is discussed.\n                  <\/jats:p>","DOI":"10.1111\/febs.14097","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T12:37:32Z","timestamp":1493815052000},"page":"2579-2591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Oxidative stress in malaria and artemisinin combination therapy: Pros and Cons"],"prefix":"10.1111","volume":"284","author":[{"given":"Reginald A.","family":"Kavishe","sequence":"first","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology Faculty of Medicine Kilimanjaro Christian Medical University College Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan B.","family":"Koenderink","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Radboud Institute for Molecular Life Sciences Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Alifrangis","sequence":"additional","affiliation":[{"name":"Centre for Medical Parasitology University of Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"WHO(2015)World malaria report\u20102015. pp.1\u2013157.WHO Geneva."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00717727"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20020793"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(99)00008-0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00059-3"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.21.5.819"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7027441"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M610737200"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2003.09.011"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(02)00423-X"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903419106"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms131216346"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134633"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1987.tb02198.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/314780"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1995.53.532"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.77.617"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60985-0"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/95.5.285"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2007.08.001"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.64.070195.000525"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.61.070192.001105"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.03.034"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04257.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.9.25"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(96)02651-X"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.5.2936"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051454398"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2325"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400181101"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1197"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540305101206"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700339200"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1227"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2001.02005.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04611.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(01)00219-5"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05303.x"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.12.022"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2003.03495.x"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2005.129"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00878-4"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.5.1227.1227"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(02)00160-3"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2009.05.011"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2002.086"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.051891106"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-007-0836-9"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(96)00152-X"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1997.11813174"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1501023112"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1999.00387.x"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(98)00170-4"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00396-4"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)02255-1"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.69.366"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-148"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565010-00004"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.090407"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.086488"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.11.3613.bloodjournal84113613"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.47.31103"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-016-1265-y"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.09.68"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10111"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(02)00117-5"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.27.19383"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.10.015"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20060986"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt486"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0010036"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2007.04.004"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/170.4.971"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(95)90094-2"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.60.936"},{"key":"e_1_2_11_77_1","unstructured":"WHO(2001)Antimalarial drug combination therapy: report of a WHO Technical Consultation.Geneva.http:\/\/apps.who.int\/iris\/bitstream\/10665\/66952\/1\/WHO_CDS_RBM_2001.35.pdf"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.1.135"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1086\/344901"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30409-1"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.03.024"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30020-2"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0649-8"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12847"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02505-8"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-284"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir486"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-264"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2007.03.005"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.113.5.1033"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.8.2418-2423.2003"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16767-6"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074045"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1086\/507115"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30415-7"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12876"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.EI10-0013-2016"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164963"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(94)90469-3"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.20256"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-016-1091-4"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.6.1393"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw388"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ffebs.14097","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.14097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T07:58:37Z","timestamp":1694505517000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.14097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,25]]},"references-count":102,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/febs.14097"],"URL":"https:\/\/doi.org\/10.1111\/febs.14097","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,25]]},"assertion":[{"value":"2016-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}