{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T22:55:23Z","timestamp":1778021723971,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["17\u201004\u201001045"],"award-info":[{"award-number":["17\u201004\u201001045"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Neonatal kidney injury is a frequent pathology, especially among premature infants. The search for effective nephroprotection requires the creation of adequate experimental models of nephropathy in newborns. In this study, we explored the development of acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>) in neonatal rats during hypoxia or administration of endotoxin. We found that 2\u2010h hypoxia (8% O<jats:sub>2<\/jats:sub>) and the intraperitoneal injection of 4 mg\u00b7kg<jats:sup>\u22121<\/jats:sup> lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>) causes the appearance of <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> markers, such as kidney injury molecule\u20101 (\u041aIM\u20101) and neutrophil gelatinase\u2010associated lipocalin (<jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content>) in the rat urine after 24 and 72 h of exposure. On the other hand, the levels of blood urine nitrogen under the same conditions rise only slightly. The damaging effects of hypoxia and endotoxin were accompanied by histological changes in the renal tissue and a significant decrease in the proliferation marker, (<jats:styled-content style=\"fixed-case\">proliferating cell nuclear antigen<\/jats:styled-content>). It is revealed that 3 h after the introduction of <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>, levels of reactive oxygen species in the kidney were significantly increased, and the injection of the antioxidant <jats:italic>N<\/jats:italic>\u2010acetylcysteine afforded protection from <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>, evaluated by urine \u041aIM\u20101 and <jats:styled-content style=\"fixed-case\">NGAL<\/jats:styled-content> levels. Thus, the simulation of <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> in newborn rat pups can be employed in screening for potential nephroprotective drugs, particularly among antioxidative compounds to be used in neonatology.<\/jats:p>","DOI":"10.1111\/febs.14177","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T15:16:37Z","timestamp":1500304597000},"page":"3069-3078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The role of oxidative stress in acute renal injury of newborn rats exposed to hypoxia and endotoxin"],"prefix":"10.1111","volume":"284","author":[{"given":"Egor Y.","family":"Plotnikov","sequence":"first","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V. Lomonosov Moscow State University Russia"},{"name":"V. I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology Ministry of Health of the Russian Federation Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana A.","family":"Pavlenko","sequence":"additional","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V. Lomonosov Moscow State University Russia"},{"name":"Russian Cardiology Research and Production Center Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina B.","family":"Pevzner","sequence":"additional","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V. Lomonosov Moscow State University Russia"},{"name":"V. I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology Ministry of Health of the Russian Federation Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljubava D.","family":"Zorova","sequence":"additional","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V. Lomonosov Moscow State University Russia"},{"name":"V. I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology Ministry of Health of the Russian Federation Moscow Russia"},{"name":"International Laser Center M.V. Lomonosov Moscow State University Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasily N.","family":"Manskikh","sequence":"additional","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V. Lomonosov Moscow State University Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis N.","family":"Silachev","sequence":"additional","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V. Lomonosov Moscow State University Russia"},{"name":"V. I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology Ministry of Health of the Russian Federation Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennady T.","family":"Sukhikh","sequence":"additional","affiliation":[{"name":"V. I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology Ministry of Health of the Russian Federation Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry B.","family":"Zorov","sequence":"additional","affiliation":[{"name":"A.N. Belozersky Institute of Physico\u2010Chemical Biology M.V. Lomonosov Moscow State University Russia"},{"name":"V. I. 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