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Deuterium\u2010reinforced polyunsaturated fatty acids (D\u2010<jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content>s) are more resistant to the reactive oxygen species\u2010initiated chain reaction of <jats:styled-content style=\"fixed-case\">LPO<\/jats:styled-content> than regular hydrogenated (H\u2010) <jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content>s. We investigated the effect of D\u2010<jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content> treatment on <jats:styled-content style=\"fixed-case\">LPO<\/jats:styled-content> and cognitive performance in aldehyde dehydrogenase 2 (<jats:italic>Aldh2<\/jats:italic>) null mice, an established model of oxidative stress\u2010related cognitive impairment that exhibits <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010like pathologies. Mice were fed a Western\u2010type diet containing either D\u2010 or H\u2010<jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content>s for 18 weeks. D\u2010<jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content> treatment markedly decreased cortex and hippocampus F<jats:sub>2<\/jats:sub>\u2010isoprostanes by approximately 55% and prostaglandin F<jats:sub>2\u03b1<\/jats:sub> by 20\u201325% as compared to H\u2010<jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content> treatment. D\u2010<jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content>s consistently improved performance in cognitive\/memory tests, essentially resetting performance of the D\u2010<jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content>\u2010fed <jats:italic>Aldh2<\/jats:italic><jats:sup><jats:italic>\u2212<\/jats:italic>\/<jats:italic>\u2212<\/jats:italic><\/jats:sup> mice to that of wild\u2010type mice fed a typical laboratory diet. D\u2010<jats:styled-content style=\"fixed-case\">PUFA<\/jats:styled-content>s therefore represent a promising new strategy to broadly reduce rates of <jats:styled-content style=\"fixed-case\">LPO<\/jats:styled-content>, and combat cognitive decline in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/febs.14291","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T06:16:47Z","timestamp":1507789007000},"page":"4083-4095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Deuterium\u2010reinforced polyunsaturated fatty acids improve cognition in a mouse model of sporadic Alzheimer's disease"],"prefix":"10.1111","volume":"284","author":[{"given":"Ahmed","family":"Elharram","sequence":"first","affiliation":[{"name":"Department of Biomedical &amp; Molecular Sciences and Centre for Neuroscience Studies Faculty of Health Sciences Queen's University Kingston Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Czegledy","sequence":"additional","affiliation":[{"name":"Department of Biomedical &amp; Molecular Sciences and Centre for Neuroscience Studies Faculty of Health Sciences Queen's University Kingston Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Golod","sequence":"additional","affiliation":[{"name":"Department of Biomedical &amp; Molecular Sciences and Centre for Neuroscience Studies Faculty of Health Sciences Queen's University Kingston Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginger L.","family":"Milne","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Vanderbilt University Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Pollock","sequence":"additional","affiliation":[{"name":"Stable Isotope Laboratory University of Arkansas Fayetteville AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Biomedical &amp; Molecular Sciences and Centre for Neuroscience Studies Faculty of Health Sciences Queen's University Kingston Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail S.","family":"Shchepinov","sequence":"additional","affiliation":[{"name":"Retrotope, Inc. 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