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The parasites are transmitted by the tsetse fly and occur exclusively in sub\u2010Saharan Africa. <jats:italic>T. brucei<\/jats:italic> are not only lethal pathogens but have also become model organisms for molecular parasitology. We focus here on membrane transport proteins of <jats:italic>T. brucei<\/jats:italic>, their contribution to homeostasis and metabolism in the context of a parasitic lifestyle, and their pharmacological role as potential drug targets or routes of drug entry. Transporters and channels in the plasma membrane are attractive drug targets as they are accessible from the outside. Alternatively, they can be exploited to selectively deliver harmful substances into the trypanosome's interior. Both approaches require the targeted transporter to be essential: in the first case to kill the trypanosome, in the second case to prevent drug resistance due to loss of the transporter. By combining functional and phylogenetic analyses, we were mining the <jats:italic>T. brucei<\/jats:italic> predicted proteome for transporters of pharmacological significance. Here, we review recent progress in the identification of transporters of lipid precursors, amino acid permeases and ion channels in <jats:italic>T. brucei<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/febs.14302","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T08:26:40Z","timestamp":1508833600000},"page":"1012-1023","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Transporters of <i>Trypanosoma brucei<\/i>\u2014phylogeny, physiology, pharmacology"],"prefix":"10.1111","volume":"285","author":[{"given":"Remo S.","family":"Schmidt","sequence":"first","affiliation":[{"name":"Swiss Tropical and Public Health Institute Basel Switzerland"},{"name":"University of Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan P.","family":"Mac\u00eado","sequence":"additional","affiliation":[{"name":"Institute of Plant Sciences University of Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Steinmann","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Molecular Medicine University of Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amaia Gonz\u00e1lez","family":"Salgado","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Molecular Medicine University of Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"B\u00fctikofer","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Molecular Medicine University of Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin","family":"Sigel","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Molecular Medicine University of Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Rentsch","sequence":"additional","affiliation":[{"name":"Institute of Plant Sciences University of Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"M\u00e4ser","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute Basel Switzerland"},{"name":"University of Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,13]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organization(2013)Control and surveillance of human African trypanosomiasis.WHO Tech. 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