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It plays a role in basic biological functions, such as cell division, differentiation, fertilization and cell death, and is involved in developmental processes including learning, memory and behavior. Deregulation of neuronal calcium signaling results in disturbance of cell homeostasis, synaptic loss and dysfunction, eventually leading to cell death. Three\n                    <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\n                    <jats:sub>3<\/jats:sub>\n                    R subtypes have been identified in mammalian cells and the predominant isoform in neurons is\n                    <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\n                    <jats:sub>3<\/jats:sub>\n                    R type 1. Dysfunction of\n                    <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\n                    <jats:sub>3<\/jats:sub>\n                    R type 1 may play a role in the pathogenesis of certain neurodegenerative diseases as enhanced activity of the\n                    <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\n                    <jats:sub>3<\/jats:sub>\n                    R was observed in models of Huntington's disease, spinocerebellar ataxias and Alzheimer's disease. These results suggest that\n                    <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\n                    <jats:sub>3<\/jats:sub>\n                    R\u2010mediated signaling is a potential target for treatment of these disorders. In this review we discuss the structure, functions and regulation of the\n                    <jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\n                    <jats:sub>3<\/jats:sub>\n                    R in healthy neurons and in conditions of neurodegeneration.\n                  <\/jats:p>","DOI":"10.1111\/febs.14366","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T12:36:40Z","timestamp":1513600600000},"page":"3547-3565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Inositol 1,4,5\u2010trisphosphate receptors and neurodegenerative disorders"],"prefix":"10.1111","volume":"285","author":[{"given":"Polina A.","family":"Egorova","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Neurodegeneration Peter the Great St. Petersburg Polytechnic University St Petersburg 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