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Mutation of proteins restricted to the alveolar type <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> pneumocyte can lead to inherited forms of pulmonary fibrosis, but even sporadic cases of pulmonary fibrosis appear to be strongly associated with activation of the unfolded protein response and\/or the integrated stress response. Inhalation of smoke can impair protein folding and may be an important cause of pulmonary <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress. Similarly, tissue hypoxia can lead to impaired protein homeostasis (proteostasis). But the mechanisms linking smoke and hypoxia to <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress are only partially understood. In this review, we will examine the role of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress in the pathogenesis of lung disease by focusing on fibrosis, smoke, and hypoxia.<\/jats:p>","DOI":"10.1111\/febs.14381","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T16:06:47Z","timestamp":1515686807000},"page":"322-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Pulmonary endoplasmic reticulum stress\u2014scars, smoke, and suffocation"],"prefix":"10.1111","volume":"286","author":[{"given":"Jennifer A.","family":"Dickens","sequence":"first","affiliation":[{"name":"Cambridge Institute for Medical Research (CIMR) University of Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Malzer","sequence":"additional","affiliation":[{"name":"Cambridge Institute for Medical Research (CIMR) University of Cambridge 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