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Endoplasmic reticulum (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>) stress and unfolded protein response (<jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content>) signaling have been detected in many diverse ocular diseases, and chemical and genetic approaches to modulate <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress and specific <jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content> regulatory molecules have shown beneficial effects in animal models of eye disease. 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