{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:36:26Z","timestamp":1791412586056,"version":"4.3.3"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T00:00:00Z","timestamp":1545436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5K12HD028820\u201022"],"award-info":[{"award-number":["5K12HD028820\u201022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Chorioamnionitis is an intrauterine infection involving inflammation of the chorion, amnion, and placenta. It leads to a fetal systemic inflammatory response that can alter the transcription of neonatal immune genes. We have previously shown that neonatal monocytes gain the activating histone tail modification H3K4me3 at promoter sites of immunologically important genes as development progresses from preterm neonate to adult. In this study, we applied Ch<jats:styled-content style=\"fixed-case\">IP<\/jats:styled-content>\u2010seq and <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010seq to evaluate the impact of chorioamnionitis on the neonatal monocyte H3K4me3 histone modification landscape over the course of fetal and neonatal immune system development. Chorioamnionitis exposure in neonatal monocytes resulted in a net increase in total monocyte H3K4me3, primarily in introns and intergenic regions. Immune gene expression was decreased in chorioamnionitis\u2010exposed monocytes, with the majority of enriched transcripts falling into pathways that are not linked to the immune system. Over half of all neonatal monocyte H3K4me3 peaks, independent of their location, were associated with active gene transcription. Overall, chorioamnionitis exposure resulted in the global remodeling of the neonatal monocyte H3K4me3 landscape and changes in the expression of known immune genes. These changes resulted in a less robust inflammatory response upon exposure to a secondary challenge, which may explain why chorioamnionitis\u2010exposed neonates have an increased risk of sepsis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Database<\/jats:title><jats:p>ChIP\u2010seq data for U30\/O30\/Term: GEO <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE81957\">GSE81957<\/jats:ext-link><\/jats:p><jats:p>ChIP\u2010seq data for U30C\/O30C\/TermC: GEO <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE111873\">GSE111873<\/jats:ext-link><\/jats:p><jats:p>RNA\u2010seq data for U\/L\/CU\/CL: GEO <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE111927\">GSE111927<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/febs.14728","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T07:14:51Z","timestamp":1545203691000},"page":"82-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Chorioamnionitis exposure remodels the unique histone modification landscape of neonatal monocytes and alters the expression of immune pathway genes"],"prefix":"10.1111","volume":"286","author":[{"given":"Jennifer","family":"Bermick","sequence":"first","affiliation":[{"name":"Division of Neonatal\u2010Perinatal Medicine Department of Pediatrics Michigan Medicine Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Surgery Michigan Medicine Ann Arbor MI 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