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A hallmark of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress is the accumulation of misfolded and unfolded proteins. Physiological levels of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress trigger the unfolded protein response (<jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content>) that is required to restore normal <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> functions. However, the <jats:styled-content style=\"fixed-case\">UPR<\/jats:styled-content> can also initiate a cell death program\/apoptosis pathway in response to excessive or persistent <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress. Recently, it has become evident that chronic <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress occurs in several diseases, including skin diseases such as Darier's disease, rosacea, vitiligo and melanoma; furthermore, it is suggested that <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress is directly involved in the pathogenesis of these disorders. Here, we review the role of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress in skin function, and discuss its significance in skin diseases.<\/jats:p>","DOI":"10.1111\/febs.14739","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T14:23:47Z","timestamp":1545834227000},"page":"413-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Insights into the role of endoplasmic reticulum stress in skin function and associated diseases"],"prefix":"10.1111","volume":"286","author":[{"given":"Kyungho","family":"Park","sequence":"first","affiliation":[{"name":"Department of Food Science and Nutrition Convergence Program of Material Science for Medicine and Pharmaceutics Hallym University Chuncheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology 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