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Oligomerization of\n                    <jats:styled-content style=\"fixed-case\">RLR<\/jats:styled-content>\n                    s following binding to cytosolic ds\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    activates and nucleates self\u2010assembly of the mitochondrial antiviral\u2010signaling protein (\n                    <jats:styled-content style=\"fixed-case\">MAVS<\/jats:styled-content>\n                    ). In the current signaling model, the caspase recruitment domains of\n                    <jats:styled-content style=\"fixed-case\">MAVS<\/jats:styled-content>\n                    form helical fibrils that self\u2010propagate like prions to promote signaling complex assembly. However, there is no conclusive evidence that\n                    <jats:styled-content style=\"fixed-case\">MAVS<\/jats:styled-content>\n                    forms fibrils in cells or with the transmembrane anchor present. We show here with super\u2010resolution light microscopy that\n                    <jats:styled-content style=\"fixed-case\">MAVS<\/jats:styled-content>\n                    activation by ds\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    induces mitochondrial membrane remodeling. Quantitative image analysis at imaging resolutions as high as 32 nm shows that in the cellular context,\n                    <jats:styled-content style=\"fixed-case\">MAVS<\/jats:styled-content>\n                    signaling complexes and the fibrils within them are smaller than 80 nm. The transmembrane domain of\n                    <jats:styled-content style=\"fixed-case\">MAVS<\/jats:styled-content>\n                    is required for its membrane remodeling, interferon signaling, and proapoptotic activities. We conclude that membrane tethering of\n                    <jats:styled-content style=\"fixed-case\">MAVS<\/jats:styled-content>\n                    restrains its polymerization and contributes to mitochondrial remodeling and apoptosis upon ds\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    sensing.\n                  <\/jats:p>","DOI":"10.1111\/febs.14772","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T13:21:13Z","timestamp":1549286473000},"page":"1543-1560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["<scp>MAVS<\/scp>\n                    polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling"],"prefix":"10.1111","volume":"286","author":[{"given":"Ming\u2010Shih","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Medicine University of Cambridge 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