{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:44:19Z","timestamp":1789911859567,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402507"],"award-info":[{"award-number":["81402507"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>\n                    Diabetic cardiomyopathy (\n                    <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                    )\u2014ventricular dysfunction in the absence of underlying heart disease\u2014is a common complication of diabetes and a leading cause of mortality associated with the disease. In\n                    <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                    , cardiac fibrosis is the main cause of heart failure. Although it is well\u2010established that the transforming growth factor\u2010beta signaling pathway plays a part in inducing cardiac fibrosis in\n                    <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                    , details of the molecular mechanism involved remain elusive. Therefore, it is crucial to study the gene reg;ulation of key signaling effectors in\n                    <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                    \u2010associated cardiac fibrosis. A recently emerged hotspot in the field of gene regulation is the role of long noncoding\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s (lnc\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s). Recent evidence indicates that lnc\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s play a critical role in cardiac fibrosis; however, in\n                    <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                    , the function of these regulatory\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s have not been studied in depth. In this study, we identified a conserved cardiac\u2010specific lnc\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    named colorectal neoplasia differentially expressed (Crnde). By analyzing 376 human heart tissues, it was found that Crnde expression is negatively correlated with that of cardiac fibrosis marker genes. Moreover, Crnde expression was shown to be enriched in cardiac fibroblasts (\n                    <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>\n                    s). Overexpression of Crnde attenuated cardiac fibrosis and enhanced cardiac function in mice with\n                    <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                    . Further,\n                    <jats:italic>in vitro<\/jats:italic>\n                    experiments showed that Crnde negatively regulates the myofibroblast differentiation of\n                    <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>\n                    s. The expression of Crnde was activated by SMAD family member 3 (Smad3), shedding light on the underlying molecular mechanism. Interestingly, Crnde also inhibited the transcriptional activation of Smad3 on target genes, thereby inhibiting the expression of myofibroblastic marker genes in\n                    <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>\n                    s. Overall, our data provide valuable insights into the development of potential anti\u2010cardiac fibrosis strategies centered on lnc\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s, for the treatment of\n                    <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/febs.14780","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T10:56:09Z","timestamp":1549968969000},"page":"1645-1655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Long noncoding\n                    <scp>RNA<\/scp>\n                    Crnde attenuates cardiac fibrosis via Smad3\u2010Crnde negative feedback in diabetic cardiomyopathy"],"prefix":"10.1111","volume":"286","author":[{"given":"Dezhi","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery The 960th Hospital of the PLA Joint Logistic Support Force Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery The 960th Hospital of the PLA Joint Logistic Support Force Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghe","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The General Hospital of Western Theater Command Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Radiology The General Hospital of Western Theater Command Chengdu 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