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It includes conventional pathologies affecting cardiovascular functions such as hypertension, atherosclerosis or thrombosis and was traditionally considered from the metabolic point of view. This Cardiovascular Continuum, originally described by Dzau and Braunwald, was extended by O'Rourke to consider also the crucial role played by degradation of elastic fibers, occurring during aging, in the appearance of vascular stiffness, another deleterious risk factor of the continuum. However, the involvement of the elastin degradation products, named elastin\u2010derived peptides, to the Cardiovascular Continuum progression has not been considered before. Data from our laboratory and others clearly showed that these bioactive peptides are central regulators of this continuum, thereby amplifying appearance and evolution of cardiovascular risk factors such as diabetes or hypertension, of vascular alterations such as atherothrombosis and calcification, but also nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. The Elastin Receptor Complex has been shown to be a crucial actor in these processes. We propose here the participation of these elastin\u2010derived peptides and of the Elastin Receptor Complex in these events, and introduce a revisited Cardiovascular Continuum based on their involvement, for which elastin\u2010based pharmacological strategies could have a strong impact in the future.<\/jats:p>","DOI":"10.1111\/febs.14836","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T13:42:44Z","timestamp":1554385364000},"page":"2980-2993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Role of elastin peptides and elastin receptor complex in metabolic and cardiovascular diseases"],"prefix":"10.1111","volume":"286","author":[{"given":"Amandine","family":"Wahart","sequence":"first","affiliation":[{"name":"UMR CNRS 7369 MEDyC SFR CAP\u2010Sant\u00e9 Universit\u00e9 de Reims Champagne\u2010Ardenne 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