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However, it is unclear whether <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content> causes depression, and the underlying mechanisms of this association remain largely unknown. In this study, mice with myocardial infarction and <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content> were used to investigate behavioral alterations as well as changes in the brain\u2010heart axis. During the first 6\u00a0months, abnormalities in neuropsychiatric behaviors were detected in mice with <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>. Using the sucrose preference test, a 9\u00a0months course of <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content> resulted in two subgroups: mice with a significant decrease in sucrose preference, defined herein as \u201csusceptible\u201d (Sus), and mice with a normal sucrose preference, defined herein as \u201cresilient.\u201d Compared to the resilient and sham\u2010operated animals, the Sus mice displayed imbalances in glutamate transmission and hypothalamic\u2013pituitary\u2013adrenal axis activation, abnormal synaptic plasticity, and increased inflammatory responses. Furthermore, abnormal kynurenine metabolism was detected in Sus mice. Our results suggest that long\u2010term <jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content> increases inflammatory responses in the central nervous system and leads to depression in Sus mice.<\/jats:p>","DOI":"10.1111\/febs.14839","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T05:42:41Z","timestamp":1554788561000},"page":"2769-2786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Inflammation associated with chronic heart failure leads to enhanced susceptibility to depression"],"prefix":"10.1111","volume":"286","author":[{"given":"Jing","family":"Su","sequence":"first","affiliation":[{"name":"Department of Translational Neuroscience Jing\u2019 an District Centre Hospital of Shanghai State Key Laboratory of Medical Neurobiology &amp; Institutes of Brain Science Fudan University China"},{"name":"School of Life Science and Technology Tongji University Shanghai 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