{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:46:40Z","timestamp":1785890800983,"version":"3.56.0"},"reference-count":131,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS064131"],"award-info":[{"award-number":["R01NS064131"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX004044"],"award-info":[{"award-number":["I01BX004044"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX007080"],"award-info":[{"award-number":["I01BX007080"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["01BX002619"],"award-info":[{"award-number":["01BX002619"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32AG000057"],"award-info":[{"award-number":["T32AG000057"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>A number of neurodegenerative diseases are characterized by deposition of abnormally phosphorylated tau or <jats:styled-content style=\"fixed-case\">TDP<\/jats:styled-content>\u201043 in disease\u2010affected neurons. These diseases include Alzheimer's disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis. No disease\u2010modifying therapeutics is available to treat these disorders, and we have a limited understanding of the cellular and molecular factors integral to disease initiation or progression. Phosphorylated tau and <jats:styled-content style=\"fixed-case\">TDP<\/jats:styled-content>\u201043 are important markers of pathology in dementia disorders and directly contribute to tau\u2010 and <jats:styled-content style=\"fixed-case\">TDP<\/jats:styled-content>\u201043\u2010related neurotoxicity and neurodegeneration. Here, we review the scope of tau and <jats:styled-content style=\"fixed-case\">TDP<\/jats:styled-content>\u201043 phosphorylation in neurodegenerative disease and discuss recent work demonstrating the kinases <jats:styled-content style=\"fixed-case\">TTBK<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">TTBK<\/jats:styled-content>2 phosphorylate both tau and <jats:styled-content style=\"fixed-case\">TDP<\/jats:styled-content>\u201043, promoting neurodegeneration.<\/jats:p>","DOI":"10.1111\/febs.14866","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T01:16:13Z","timestamp":1556673373000},"page":"2434-2446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Tau tubulin kinases in proteinopathy"],"prefix":"10.1111","volume":"286","author":[{"given":"Laura M.","family":"Taylor","sequence":"first","affiliation":[{"name":"Division of Gerontology and Geriatric Medicine Department of Medicine University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"McMillan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of Washington Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2252-7634","authenticated-orcid":false,"given":"Brian C.","family":"Kraemer","sequence":"additional","affiliation":[{"name":"Division of Gerontology and Geriatric Medicine Department of Medicine University of Washington Seattle WA USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of Washington Seattle Washington USA"},{"name":"Geriatrics Research Education and Clinical Center Veterans Affairs Puget Sound Health Care System Seattle WA USA"},{"name":"Department of Pathology University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole F.","family":"Liachko","sequence":"additional","affiliation":[{"name":"Division of Gerontology and Geriatric Medicine Department of Medicine University of Washington Seattle WA USA"},{"name":"Geriatrics Research Education and Clinical Center Veterans Affairs Puget Sound Health Care System Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.5.1858"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.6.2739"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.101.4.1371"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/369488a0"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.13.7679"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-4-13"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0909142"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6474172"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2000-2209"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5161-07.2008"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2460"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0796-783"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.13.4913"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90210-9"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.2478\/s13380-012-0032-y"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000063311.58879.01"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.631"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194653"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141736"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.036"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12491"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j845"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1210951"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0355-7"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1029-x"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1546"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0237-2"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/31508"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13103"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu223"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1964.00460160003001"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.1"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26987"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26054"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7682-y"},{"key":"e_1_2_13_38_1","first-page":"135","volume-title":"Neurodegeneration","author":"Dickson D","year":"2011"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1301175110"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-2-73"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27198"},{"key":"e_1_2_13_42_1","first-page":"pp. 165\u2013167Prag","volume-title":"\u00dcber die Bejiehungen der senilen Hir natrophie zur Aphasie in","author":"Pick A","year":"1892"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.11.1803"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1998.tb00158.x"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198605000-00011"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/37.4.422"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2015.1"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.467"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.014472"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M709715200"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505895200"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03784.x"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29715"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90259-V"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90839-Y"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb03173.x"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03365.x"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04059.x"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00955-9"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02256-6"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0237-9"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.022749"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.2741\/2727"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.06.001"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.07.023"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013250"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000193"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.132"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70071-1"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-315018"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0477-9"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181ee7d85"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0261-2"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.09.048"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21154"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31817713b5"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0463-2"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.169561"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1666-6"},{"key":"e_1_2_13_80_1","first-page":"CD001447","article-title":"Riluzole for amyotrophic lateral sclerosis (ALS)\/motor neuron disease (MND)","author":"Miller RG","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30289-2"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960802372371"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172911.39167.b6"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr195"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.011"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.010"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0659-0"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.061846"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20584"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3121"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1563"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.3961"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6845"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M800390-MCP200"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1134108"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.10.093"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21425"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23870"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.038950"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-5-33"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.07098.x"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2911-10.2010"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004803"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22150"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-150144"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.43"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3417-08.2008"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2014.00033"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201300274"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2053230X14000144"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/575170"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4248-14.2015"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12001"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.01.011"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.12.021"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.218"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.11.026"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.10.010"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007844"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12191"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201412075"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1401777111"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339039"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354441"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.202150"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-016-0786-9"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20110276"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1731-7"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26486"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.11.010"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00114"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt498"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.14866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.14866","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.14866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T02:11:09Z","timestamp":1694311869000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.14866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,22]]},"references-count":131,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/febs.14866"],"URL":"https:\/\/doi.org\/10.1111\/febs.14866","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,22]]},"assertion":[{"value":"2018-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}