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Several genetic disorders of bone and connective tissue are caused by mutations in genes encoding for glycosyltransferases, sulfotransferases and transporters that are responsible for the synthesis of sulfated\n                    <jats:styled-content style=\"fixed-case\">GAG<\/jats:styled-content>\n                    s. Phenotypically, these disorders all reflect alterations in crucial biological functions of\n                    <jats:styled-content style=\"fixed-case\">GAG<\/jats:styled-content>\n                    s in the development, growth and homoeostasis of cartilage and bone. To date, up to 27 different skeletal phenotypes have been linked to mutations in 23 genes encoding for proteins involved in\n                    <jats:styled-content style=\"fixed-case\">GAG<\/jats:styled-content>\n                    biosynthesis. This review focuses on recent genetic, molecular and biochemical studies of bone and connective tissue disorders caused by\n                    <jats:styled-content style=\"fixed-case\">GAG<\/jats:styled-content>\n                    synthesis defects. These insights and future research in the field will provide a deeper understanding of the molecular pathogenesis of these disorders and will pave the way for developing common therapeutic strategies that might be targeted to a range of individual phenotypes.\n                  <\/jats:p>","DOI":"10.1111\/febs.14984","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T02:58:36Z","timestamp":1562641116000},"page":"3008-3032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Bone and connective tissue disorders caused by defects in glycosaminoglycan biosynthesis: a panoramic view"],"prefix":"10.1111","volume":"286","author":[{"given":"Chiara","family":"Paganini","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine Unit of Biochemistry University of Pavia 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