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Here, we observed that VPA treatment inhibited HDAC1\/2 activity and induced autophagy in gastric cancer cells, leading to apoptosis. VPA\u2010induced apoptosis occurred through inhibition of the HDAC1\/PTEN\/Akt signalling pathway and involved alterations in Bcl\u20102 and Beclin\u20101. The antitumour effects of VPA were verified <jats:italic>in\u00a0vivo<\/jats:italic> using SGC\u20107901 xenograft models. Moreover, we evaluated the expression of HDAC1\/2 in gastric cancer patient samples and revealed a positive correlation between HDAC1\/2 overexpression and poor prognosis. These findings indicate that VPA may serve as a potential therapeutic agent for gastric cancer and that HDAC1\/2 might be a promising therapeutic biomarker for the disease.<\/jats:p>","DOI":"10.1111\/febs.15122","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T12:10:05Z","timestamp":1573042205000},"page":"2118-2133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Valproic acid targets HDAC1\/2 and HDAC1\/PTEN\/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer"],"prefix":"10.1111","volume":"287","author":[{"given":"Jie","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pathology and Cancer Research Center Yanbian University Medical College Yanji China"},{"name":"Key Laboratory of the Science and Technology Department of Jilin Province Yanji 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