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Here, we demonstrated that developmentally regulated GTP\u2010binding protein 2 (DRG2) is required for the growth of primary tumors and for metastasis. DRG2 expression was significantly increased in MM compared with primary melanoma (PM) and dysplastic nevi. A correlation between DRG2 expression and poor disease\u2010specific survival in melanoma patients was also identified. Furthermore, inhibition of DRG2 suppressed the binding of Hypoxia\u2010inducible factor 1\u03b1 to the\n                    <jats:italic>VEGF\u2010A<\/jats:italic>\n                    promoter region, expression of vascular endothelial growth factor (VEGF)\u2010A, and formation of endothelial cell tubes. In experimental mice, DRG2 depletion inhibited the growth of PM and lung metastases and increased survival. These results identify DRG2 as a critical regulator of\n                    <jats:italic>VEGF\u2010A<\/jats:italic>\n                    expression and of growth of PMs and lung metastases.\n                  <\/jats:p>","DOI":"10.1111\/febs.15125","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T15:46:18Z","timestamp":1573055178000},"page":"2070-2086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["DRG2 supports the growth of primary tumors and metastases of melanoma by enhancing VEGF\u2010A expression"],"prefix":"10.1111","volume":"287","author":[{"given":"Nal Ae","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Biological Sciences University of Ulsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Jin","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pathology Ulsan University Hospital University 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