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Although AMP\u2010activated protein kinase (AMPK) is a critical cellular energy sensor, it has recently become clear that AMPK can act as a tumor regulator. Here, we assessed the expression of AMPK in primary ATL cells and the effects of dorsomorphin, an AMPK inhibitor, on primary ATL cells and HTLV\u20101\u2010infected T\u2010cell lines. AMPK expression in acute and chronic ATL patients was significantly higher than in asymptomatic HTLV\u20101 carriers and healthy donors. Dorsomorphin induced apoptosis in peripheral blood mononuclear cells from ATL patients. Dorsomorphin also induced dose\u2010 and time\u2010dependent apoptosis in HTLV\u20101\u2010infected T\u2010cell lines. Dorsomorphin increased the production of intracellular reactive oxygen species (ROS) and induced ataxia telangiectasia\u2010mutated Ser1981 phosphorylation and p53 accumulation. These results indicated that dorsomorphin induces apoptosis via ROS\u2010mediated DNA damage in HTLV\u20101\u2010infected T\u2010cell lines. Furthermore, dorsomorphin suppressed the growth of human ATL tumor xenografts in NOD\/SCID mice. Together, these data suggest that AMPK could be a candidate therapeutic target for ATL and that dorsomorphin could be a therapeutic agent for ATL.<\/jats:p>","DOI":"10.1111\/febs.15239","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T13:45:32Z","timestamp":1580996732000},"page":"4005-4015","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cell death induced by dorsomorphin in adult T\u2010cell leukemia\/lymphoma is AMPK\u2010independent"],"prefix":"10.1111","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3995-0869","authenticated-orcid":false,"given":"Akiyoshi","family":"Aikawa","sequence":"first","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmaceutical Sciences Fukuoka University 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