{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:19:46Z","timestamp":1790371186817,"version":"4.1.0"},"reference-count":102,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["AM\/507\/1\u20101"],"award-info":[{"award-number":["AM\/507\/1\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["NA 1565\/2\u20101"],"award-info":[{"award-number":["NA 1565\/2\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003390","name":"Fritz Thyssen Stiftung","doi-asserted-by":"publisher","award":["10.19.1.009MN"],"award-info":[{"award-number":["10.19.1.009MN"]}],"id":[{"id":"10.13039\/501100003390","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>Skeletal muscles constitute roughly 40% of human body mass. Muscles are specialized tissues that generate force to drive movements through ATP\u2010driven cyclic interactions between the protein filaments, namely actin and myosin filaments. The filaments are organized in an intricate structure called the \u2018sarcomere\u2019, which is a fundamental contractile unit of striated skeletal and cardiac muscle, hosting a fine assembly of macromolecular protein complexes. The micrometer\u2010sized sarcomere units are arranged in a reiterated array within myofibrils of muscle cells. The precise spatial organization of sarcomere is tightly controlled by several molecular mechanisms, indispensable for its force\u2010generating function. Disorganized sarcomeres, either due to erroneous molecular signaling or due to mutations in the sarcomeric proteins, lead to human diseases such as cardiomyopathies and muscle atrophic conditions prevalent in cachexia. Protein post\u2010translational modifications (PTMs) of the sarcomeric proteins serve a critical role in sarcomere formation (sarcomerogenesis), as well as in the steady\u2010state maintenance of sarcomeres. PTMs such as phosphorylation, acetylation, ubiquitination, and SUMOylation provide cells with a swift and reversible means to adapt to an altered molecular and therefore cellular environment. Over the past years, SUMOylation has emerged as a crucial modification with implications for different aspects of cell function, including organizing higher\u2010order protein assemblies. In this review, we highlight the fundamentals of the small ubiquitin\u2010like modifiers (SUMO) pathway and its link specifically to the mechanisms of sarcomere assembly. Furthermore, we discuss recent studies connecting the SUMO pathway\u2010modulated protein homeostasis with sarcomere organization and muscle\u2010related pathologies.<\/jats:p>","DOI":"10.1111\/febs.15263","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T15:29:25Z","timestamp":1582644565000},"page":"2176-2190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["SUMO system \u2013 a key regulator in sarcomere organization"],"prefix":"10.1111","volume":"287","author":[{"given":"Arnab","family":"Nayak","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cell Physiology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8582-3986","authenticated-orcid":false,"given":"Mamta","family":"Amrute\u2010Nayak","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Physiology Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11180"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/173971a0"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2010.11.006"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90054-X"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-019-02260-9"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0054-2"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2307"},{"key":"e_1_2_14_9_1","first-page":"136","article-title":"Muscle paralysis and myosin loss in a patient with cancer cachexia","volume":"26","author":"Banduseela V","year":"2007","journal-title":"Acta Myol"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12559"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005489319058"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1198"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-84847-1_1"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10974-009-9189-6"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013341"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.137067"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/569628"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R110.174268"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.124941"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021317-121234"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01144-9"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.14.5434"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90585-X"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01874"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.05.046"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201010090"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv046"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.002"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-110711-155603"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1241904"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.08.008"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.37"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06145"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001390"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.54"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8935-4-16"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13956"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-018-0217-x"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1316"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.07.001"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cm.970280102"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200210001-00018"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.02.032"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22851"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.12.012"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00606-5"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.183897"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00858.2001"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw069"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M710277200"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-013-0435-6"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.11.020"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061909-093311"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1515\/bmc-2016-0030"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1413825111"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6409"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104214200"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.10.010"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00630-X"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.02.001"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.10.007"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201438534"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.038570"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00651-08"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3185"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.04.006"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.73.011303.074118"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2293"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.211904"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2007.05.002"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0422-2"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.12.019"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.08.031"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2010.206"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2526"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2016-000031"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600523"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.112"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025852"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaa2213"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0717-y"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2001484"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.12.027"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.10.021"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.O114.044792"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.02.033"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.05.011"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2011.228"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.6.2273-2287.2005"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.03.016"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.518282"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.463257"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1465-9"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.236"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.150334"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10974-008-9137-x"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf7099"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307730"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M116.066159"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjy036"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.107"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10407"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0115"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ffebs.15263","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.15263","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.15263","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.15263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T12:27:51Z","timestamp":1694003271000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.15263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,13]]},"references-count":102,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/febs.15263"],"URL":"https:\/\/doi.org\/10.1111\/febs.15263","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,13]]},"assertion":[{"value":"2019-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}