{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:08:40Z","timestamp":1780384120467,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BIVMiB041"],"award-info":[{"award-number":["BIVMiB041"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>The <jats:italic>scsABCD<\/jats:italic> (suppressor of copper sensitivity) locus of <jats:italic>Salmonella<\/jats:italic> encodes four proteins that resemble the disulfide folding machinery of other bacteria. Previous work has shown that <jats:italic>Salmonella<\/jats:italic> encounters toxic levels of copper during infection and the Scs system provides protection against this copper\u2010mediated toxicity. The current work reports that expression of the soluble periplasmic protein StScsC is induced by copper and that intramacrophage survival in the presence of copper is diminished by the loss of StScsC. Using a combination of genetic and proteomic approaches, the abundance of various cysteine\u2010containing periplasmic proteins was found to be elevated by StScsC in the <jats:italic>Salmonella<\/jats:italic> periplasm, implicating StScsC in the disulfide folding of superoxide dismutases and proteins involved in amino acid sensing and import. Co\u2010purification and mass spectrometry approaches confirmed that the arginine\u2010sensing periplasmic protein ArtI associates with StScsC via a disulfide interaction, and purified ArtI was shown to alter the thiol redox state of purified StScsC. This work reports the first demonstration of a redox partner for the Scs system of <jats:italic>Salmonella<\/jats:italic> and provides insights into how this bacterial pathogen responds to copper stress during infection.<\/jats:p>","DOI":"10.1111\/febs.15285","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:55:13Z","timestamp":1583801713000},"page":"3827-3840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The copper\u2010responsive ScsC protein of <i>Salmonella<\/i> promotes intramacrophage survival and interacts with the arginine sensor ArtI"],"prefix":"10.1111","volume":"287","author":[{"given":"Buke","family":"Yucel","sequence":"first","affiliation":[{"name":"RAPID Group School of Biosciences University of Kent Canterbury UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary K.","family":"Robinson","sequence":"additional","affiliation":[{"name":"RAPID 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