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In recent years, it has been found that multiple long noncoding RNAs (lncRNAs) participate in a wide range of biological functions including angiogenesis through the regulation of gene expression in cancers. In this study, we investigate and report the novel role of lncRNA SLC26A4\u2010AS1 in gliomas, with a novel mechanism involving transcription factors NFKB1 and NPTX1. We determined that SLC26A4\u2010AS1 was downregulated in human glioma tissues and cells. Furthermore, overexpression of SLC26A4\u2010AS1 or NPTX1 restrained the aggressiveness of glioma cells and their pro\u2010angiogenic ability. SLC26A4\u2010AS1 was also found to upregulate NPTX1 by recruiting NFKB1 into the NPTX1 promoter. Moreover, silencing of either NPTX1 or NFKB1 restored the aggressive and pro\u2010angiogenic properties of glioma cells in the presence of SLC26A4\u2010AS1. Taken together, we demonstrate that SLC26A4\u2010AS1 promotes NPTX1 transcriptional activity by recruiting NFKB1 and thus exerting antiangiogenic effects on glioma cells. This study provides an experimental basis for the intervention of SLC26A4\u2010AS1 in the treatment of gliomas.<\/jats:p>","DOI":"10.1111\/febs.15325","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T09:56:06Z","timestamp":1586253366000},"page":"212-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Long non coding RNA SLC26A4\u2010AS1 exerts antiangiogenic effects in human glioma by upregulating NPTX1 via NFKB1 transcriptional factor"],"prefix":"10.1111","volume":"288","author":[{"given":"Haijun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Taizhou Second People's Hospital China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoyu","family":"Yan","sequence":"additional","affiliation":[{"name":"Ankang Ward Taizhou Second People's Hospital 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