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However, the functional and structural significance of disordered regions in the JEV proteome has not been systematically investigated as of yet. To fill this gap, we used here a set of bioinformatics tools to analyze the JEV proteome for the predisposition of its proteins for intrinsic disorder and for the presence of the disorder\u2010based binding regions (also known as molecular recognition features, MoRFs). We also analyzed all JEV proteins for the presence of the probable nucleic acid\u2010binding (DNA and RNA) sites. The results of these computational studies are experimentally validated using JEV capsid protein as an illustrative example. In agreement with bioinformatic analysis, we found that the N\u2010terminal region of the JEV capsid (residues 1\u201330) is intrinsically disordered. We showed that this region is characterized by the temperature response typical for highly disordered proteins. Furthermore, we have experimentally shown that this disordered N\u2010terminal domain of a capsid protein has a noticeable \u2018gain\u2010of\u2010structure\u2019 potential. In addition, using DOPS liposomes, we demonstrated the presence of pronounced membrane\u2010mediated conformational changes in the N\u2010terminal region of JEV capsid. In our view, this disorder\u2010centric analysis would be helpful for a better understanding of the JEV pathogenesis.<\/jats:p>","DOI":"10.1111\/febs.15427","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T21:12:53Z","timestamp":1590873173000},"page":"3751-3776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Japanese encephalitis virus \u2013 exploring the dark proteome and disorder\u2013function paradigm"],"prefix":"10.1111","volume":"287","author":[{"given":"Taniya","family":"Bhardwaj","sequence":"first","affiliation":[{"name":"School of Basic Sciences Indian Institute of Technology Mandi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar Udit","family":"Saumya","sequence":"additional","affiliation":[{"name":"School of Basic Sciences Indian Institute of Technology Mandi 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