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The identification of the first fragments of <jats:italic>DMD<\/jats:italic> gene cDNA in 1986, prediction of the entire 3685 amino acid protein sequence, and production of antibodies to dystrophin, both in 1987, provided key tools to understand DMD genetics and molecular pathology. The identification of dystrophin nucleated extensive research on myofiber membrane cytoskeleton, membrane repair, muscle regeneration, and failure of regeneration. This in turn led to molecular therapeutics based on understanding of dystrophin structure and function. This historical perspective describes the events surrounding the initial identification of the dystrophin protein.<\/jats:p>","DOI":"10.1111\/febs.15466","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T08:54:37Z","timestamp":1593593677000},"page":"3879-3887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["The discovery of dystrophin, the protein product of the Duchenne muscular dystrophy gene"],"prefix":"10.1111","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6470-5139","authenticated-orcid":false,"given":"Eric P.","family":"Hoffman","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences School of Pharmacy and Pharmaceutical Sciences Binghamton University \u2013 State University of New York Binghamton NY 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