{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:08:02Z","timestamp":1792292882324,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671444"],"award-info":[{"award-number":["31671444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871352 31991190"],"award-info":[{"award-number":["31871352 31991190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>The novel coronavirus SARS\u2010CoV\u20102 is the causative agent of the global coronavirus disease 2019 (COVID\u201019) outbreak. In addition to pneumonia, other COVID\u201019\u2010associated symptoms have been reported, including loss of smell (anosmia). However, the connection between infection with coronavirus and anosmia remains enigmatic. It has been reported that defects in olfactory cilia lead to anosmia. In this Viewpoint, we summarize transmission electron microscopic studies of cilia in virus\u2010infected cells. In the human nasal epithelium, coronavirus infects the ciliated cells and causes deciliation. Research has shown that viruses such as influenza and Sendai attach to the ciliary membrane. The Sendai virus enters cilia by fusing its viral membrane with the ciliary membrane. A recent study on SARS\u2010CoV\u20102\u2013human protein\u2013protein interactions revealed that the viral nonstructural protein Nsp13 interacts with the centrosome components, providing a potential molecular link. The mucociliary escalator removes inhaled pathogenic particles and functions as the first line of protection mechanism against viral infection in the human airway. Thus, future investigation into the virus\u2013cilium interface will help further the battle against COVID\u201019.<\/jats:p>","DOI":"10.1111\/febs.15491","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T13:12:24Z","timestamp":1595337144000},"page":"3672-3676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["COVID\u201019, cilia, and smell"],"prefix":"10.1111","volume":"287","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"School of Medicine Tsinghua University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4137-5290","authenticated-orcid":false,"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Tsinghua\u2010Peking Center for Life Sciences Beijing Frontier Research Center for Biological Structure McGovern Institute for Brain Research School of Life Sciences MOE Key Laboratory for Protein Science Tsinghua University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1512-7824","authenticated-orcid":false,"given":"Guangshuo","family":"Ou","sequence":"additional","affiliation":[{"name":"Tsinghua\u2010Peking Center for Life Sciences Beijing Frontier Research Center for Biological Structure McGovern Institute for Brain Research School of Life Sciences MOE Key Laboratory for Protein Science Tsinghua University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30251-8"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.37"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqaa029"},{"key":"e_1_2_12_6_1","first-page":"174","article-title":"SARS\u2010CoV\u20102, SARS\u2010CoV, and MERS\u2010COV: a comparative overview, Le infezioni in medicina","volume":"28","author":"Rabaan AA","year":"2020","journal-title":"Infez Med"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9030231"},{"key":"e_1_2_12_8_1","volume-title":"Coronavirus Disease 2019 (COVID\u201019) Pandemic, 2020","author":"World Health Organization","year":"2020"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22579"},{"key":"e_1_2_12_11_1","article-title":"Coincidence of COVID\u201019 epidemic and olfactory dysfunction outbreak","author":"Bagheri SHR","year":"2020","journal-title":"medRxiv"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa330"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2020.152184"},{"key":"e_1_2_12_14_1","volume-title":"Symptoms of Coronavirus","author":"Centers for Disease Control and Prevention","year":"2020"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63855-7.00005-8"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.60"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00194614"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb7314"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.20105114"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0868-6"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000381"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13413-7"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210101204"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-9-1-77"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2286-9"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.63"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00709-013-0488-9"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00193-X"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ffebs.15491","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.15491","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.15491","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.15491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:33:04Z","timestamp":1693344784000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.15491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":27,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/febs.15491"],"URL":"https:\/\/doi.org\/10.1111\/febs.15491","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,6]]},"assertion":[{"value":"2020-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}