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It is clear now that the virus can cause far more damage in patients with comorbid conditions\u2014particularly in those with respiratory, cardiovascular, or immune\u2010compromised system\u2014than in patients without such comorbidities. Drug use can further exacerbate the condition. In this regard, the ill effects of smoking are amply documented, and no doubt can be a confounding factor in COVID\u201019 progression. Although conflicting hypotheses on the potential role of nicotine in COVID\u201019 pathology have recently been offered, we believe that nicotine itself, through its interaction with the nicotinic cholinergic system, as well as ACE2, may not only be of use in a variety of neuropsychiatric and neurodegenerative diseases, but may also be of potential use in COVID\u201019. Thus, on one hand, while we strongly support smoking cessation as a means of harm reduction associated with COVID\u201019, on the other hand, we support a potential therapeutic role for nicotine, nicotinic agonists, or positive allosteric modulators of nicotinic cholinergic receptors in COVID\u201019, owing to their varied effects including mood regulation, anti\u2010inflammatory, and purported interference with SARS\u2010CoV\u20102 entry and\/or replication.<\/jats:p>","DOI":"10.1111\/febs.15521","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T17:54:19Z","timestamp":1597341259000},"page":"3656-3663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Nicotine and the nicotinic cholinergic system in COVID\u201019"],"prefix":"10.1111","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1703-1842","authenticated-orcid":false,"given":"Yousef","family":"Tizabi","sequence":"first","affiliation":[{"name":"Department of Pharmacology Howard University College of Medicine Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruk","family":"Getachew","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Howard University College of Medicine Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Copeland","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Howard University College of Medicine Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Aschner","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00547-2020"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6775"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103000"},{"key":"e_1_2_13_5_1","unstructured":"National Institute of Drug Abuse(2020)COVID\u201019: Potential implications for individuals with substance use disorders. 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