{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:10:01Z","timestamp":1775074201848,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>The coronavirus disease 2019 (COVID\u201019) pandemic has focused attention on the potential role of vitamin D supplementation to prevent COVID\u201019. In this issue, Merzon and colleagues report epidemiologic data on the vitamin D status of 7807 individuals and their risk of developing COVID\u201019. In multivariable analyses, low vitamin D status was associated with increased risk of both COVID\u201019 infection and hospitalization. The authors call for clinical trials of vitamin D supplementation. In this Commentary, we discuss some of the challenges of vitamin D research and provide recommendations for the design of randomized controlled trials of vitamin D supplementation to prevent COVID\u201019.<\/jats:p><jats:p>Comment on: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/doi.org\/10.1111\/febs.15495\">https:\/\/doi.org\/10.1111\/febs.15495<\/jats:ext-link><\/jats:p>","DOI":"10.1111\/febs.15534","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T08:52:10Z","timestamp":1601196730000},"page":"3689-3692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Vitamin D to prevent COVID\u201019: recommendations for the design of clinical trials"],"prefix":"10.1111","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-7654","authenticated-orcid":false,"suffix":"Jr.","given":"Carlos A.","family":"Camargo","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Massachusetts General Hospital Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian R.","family":"Martineau","sequence":"additional","affiliation":[{"name":"Institute for Population Health Sciences, Barts and The London School of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-809963-6.00112-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i6583"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.07.14.20152728"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12040988"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjnph-2020-000089"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15495"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1909"},{"key":"e_1_2_8_9_1","article-title":"Calcitriol, the active form of vitamin D, is a promising candidate for COVID\u201019 prophylaxis","author":"Mok CK","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nure.12090"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2516"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.15534","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.15534","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.15534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:32:34Z","timestamp":1693344754000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.15534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":12,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/febs.15534"],"URL":"https:\/\/doi.org\/10.1111\/febs.15534","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"2020-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}