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With the advent of high\u2010throughput <jats:italic>omics<\/jats:italic> technologies such as tissue microarray or RNA sequencing, a large number of olfactory receptors have been reported to be expressed in the nonolfactory tissues. Although these technologies uncovered the expression of these olfactory receptors in the nonchemosensory tissues, unfortunately, they failed to reveal the information about their cell type of origin. Accurate characterization of the cell types should be the first step towards devising cell type\u2010specific assays for their functional evaluation. Single\u2010cell RNA\u2010sequencing technology resolved some of these apparent limitations and opened new means to interrogate the expression of these extranasal olfactory receptors at the single\u2010cell resolution. Moreover, the availability of large\u2010scale, multi\u2010organ\/species single\u2010cell expression atlases offer ample resources for the systematic reannotation of these receptors in a cell type\u2010specific manner. In this Viewpoint article, we discuss some of the technical limitations that impede the in\u2010depth understanding of these extranasal olfactory receptors, with a special focus on odorant receptors. Moreover, we also propose a list of single cell\u2010based <jats:italic>omics<\/jats:italic> technologies that could further promulgate the opportunity to decipher the regulatory network that drives the odorant receptors expression at atypical locations.<\/jats:p>","DOI":"10.1111\/febs.15606","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T17:19:29Z","timestamp":1603300769000},"page":"4230-4241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Challenges and possible solutions for decoding extranasal olfactory receptors"],"prefix":"10.1111","volume":"288","author":[{"given":"Siddhant","family":"Kalra","sequence":"first","affiliation":[{"name":"Department of Computational Biology Indraprastha Institute of Information Technology, New Delhi, India 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