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Norepinephrine (NE)\/epinephrine (Epi) and acetylcholine (ACh) are released from cardiac ANS terminals and mediate the biological actions of the ANS on the heart via stimulation of cardiac adrenergic or muscarinic receptors, respectively. In addition, several other neurotransmitters\/hormones act as facilitators of ANS neurotransmission in the heart, taking part in the so\u2010called nonadrenergic noncholinergic (NANC) part of the ANS's control of cardiac function. These NANC mediators also use several different cell membrane\u2010residing GPCRs to exert their effects in the myocardium. Cardiac ANS dysfunction and an imbalance between the activities of its two branches underlie a variety of cardiovascular diseases, from heart failure and hypertension to coronary artery disease, myocardial ischemia, and arrhythmias. In this review, we present the main well\u2010established signaling modalities used by cardiac autonomic GPCRs, including receptors for salient NANC mediators, and we also highlight the latest developments pertaining to cardiac cell type\u2010specific signal transduction, resulting in cell type\u2010specific cardiac effects of each of these autonomic receptors.<\/jats:p>","DOI":"10.1111\/febs.15771","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T09:40:25Z","timestamp":1613641225000},"page":"2645-2659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Signaling and function of cardiac autonomic nervous system receptors: Insights from the GPCR signalling 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