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Adjuvants have been widely used to augment the magnitude and longevity of the adaptive immune responses to immunizations with HIV\u20101 Envs and to guide the development of specific immune responses. Here, we review the adjuvants that have been used in combination with HIV\u20101 Envs in several preclinical and human clinical trials in recent years. We summarize the interactions between the HIV\u20101 Envs and adjuvants, and highlight the routes of vaccine administration for various formulations. 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