{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:45:17Z","timestamp":1788954317817,"version":"build-2803163510"},"reference-count":93,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Millions of people globally suffer from allergic diseases, and the cases have been rising in the past decades. One of the major manifestations of allergic diseases is itch, which is an unpleasant symptom that triggers the urge to scratch and greatly affects the quality of life. Thus, research on how sensation of itch is detected\/transmitted from the contact of the allergen to the nervous system is crucial in mitigating itch. Recent studies have attempted to elucidate the mechanisms of itch in allergic diseases. Here, we aim to review the endogenous mediators released from immune\/nonimmune skin cells (that are indirectly involved in the propagation of itch) and the sensory neurons that express receptors for these itch mediators that are associated with direct transmission of itch in cutaneous allergic diseases. As the mechanisms for allergic itch become clearer, new therapeutic approaches to relieve itch are likely to be developed. Recent clinical trials are testing numerous compounds that target the endogenous mediators and their receptors. These studies provide the possibility of more effective itch treatment for allergic diseases.<\/jats:p>","DOI":"10.1111\/febs.15860","type":"journal-article","created":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T06:55:02Z","timestamp":1617432902000},"page":"2723-2735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The emerging role of neuroimmune interactions in atopic dermatitis and itch"],"prefix":"10.1111","volume":"289","author":[{"given":"Jennifer","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Molecular Biomedical Sciences College of Veterinary Medicine North Carolina State University  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1149-3480","authenticated-orcid":false,"given":"Santosh K.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences College of Veterinary Medicine North Carolina State University  Raleigh NC USA"},{"name":"Comparative Medicine Institute College of Veterinary Medicine North Carolina State University  Raleigh NC USA"},{"name":"Program in Genetics North Carolina State University  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,18]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"281","article-title":"The indirect costs of allergic diseases","volume":"32","author":"Strozek J","year":"2019","journal-title":"Int J Occup Med Environ Health"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxx040"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12780"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.111"},{"key":"e_1_2_11_6_1","first-page":"293","article-title":"Atopic dermatitis in children","volume":"45","author":"Strathie Page S","year":"2016","journal-title":"Aust Fam Physician"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8628-1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.04.013"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-018-0624-y"},{"key":"e_1_2_11_10_1","first-page":"1131","article-title":"Itch\u2010associated neuropeptides and their receptor expression in dog dorsal root ganglia and spinal cord","volume":"99","author":"Wheeler JJ","year":"2019","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.06.002"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1192-11.2011"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00302.2011"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.05.044"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00703.2016"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2990"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.12.029"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.09.011"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-229948"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.12.980"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.012"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2014.06.001"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.03.036"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.08.057"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.239"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201910697"},{"key":"e_1_2_11_27_1","article-title":"Transcriptome profiling reveals Th2 bias and identifies endogenous itch mediators in poison ivy contact dermatitis","volume":"5","author":"Liu B","year":"2019","journal-title":"JCI Insight"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.10"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.198"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.013"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.003"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6786-5_8"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.06.168"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.48448"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.05.117"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155\u20109899.1000110"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S257647"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18187-z"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.048"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.036244"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-017-0194-9"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307321110"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606608113"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/738625"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2018.38.4105"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133324"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.006"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20164053"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600126"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.01.036"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1682972"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2015.01.004"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2016.207"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.388"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000172"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.89362"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2016.06.003"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-012-0443-9"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545501"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12823"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01891.x"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_551_16"},{"key":"e_1_2_11_63_1","first-page":"WC06","article-title":"Comparative efficacy and safety of ebastine 20 mg, ebastine 10 mg and levocetirizine 5 mg in acute urticaria","volume":"11","author":"Goyal V","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_11_64_1","volume-title":"Fexofenadine","author":"Craun KL","year":"2020"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2016.05.014"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13644"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-86"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12904"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2011.32.3460"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00406.2011"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.13-RAI-0663"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58978"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010968"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2852"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-12-79"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402895"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704064"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.059"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610020"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804092"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.11.051"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.08.022"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.05.029"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.0079"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.08.013"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.03.018"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133774"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.131347"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2011.00803.x"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100610"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.87"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17455"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7450151"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43586"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.15860","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.15860","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.15860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T13:20:31Z","timestamp":1692969631000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.15860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,18]]},"references-count":93,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/febs.15860"],"URL":"https:\/\/doi.org\/10.1111\/febs.15860","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,18]]},"assertion":[{"value":"2020-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}