{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:55:08Z","timestamp":1792119308142,"version":"4.4.0"},"reference-count":282,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003185","name":"Fraunhofer-Gesellschaft","doi-asserted-by":"publisher","award":["Attract 069\u2010608203"],"award-info":[{"award-number":["Attract 069\u2010608203"]}],"id":[{"id":"10.13039\/501100003185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016399","name":"Universit\u00e9 de Reims Champagne-Ardenne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Elastic fibers are extracellular components of higher vertebrates and confer elasticity and resilience to numerous tissues and organs such as large blood vessels, lungs, and skin. Their formation and maturation take place in a complex multistage process called elastogenesis. It requires interactions between very different proteins but also other molecules and leads to the deposition and crosslinking of elastin\u2019s precursor on a scaffold of fibrillin\u2010rich microfibrils. Mature fibers are exceptionally resistant to most influences and, under healthy conditions, retain their biomechanical function over the life of the organism. However, due to their longevity, they accumulate damages during aging. These are caused by proteolytic degradation, formation of advanced glycation end products, calcification, oxidative damage, aspartic acid racemization, lipid accumulation, carbamylation, and mechanical fatigue. The resulting changes can lead to diminution or complete loss of elastic fiber function and ultimately affect morbidity and mortality. Particularly, the production of elastokines has been clearly shown to influence several life\u2010threatening diseases. Moreover, the structure, distribution, and abundance of elastic fibers are directly or indirectly influenced by a variety of inherited pathological conditions, which mainly affect organs and tissues such as skin, lungs, or the cardiovascular system. A distinction can be made between microfibril\u2010related inherited diseases that are the result of mutations in diverse microfibril genes and indirectly affect elastogenesis, and elastinopathies that are linked to changes in the elastin gene. This review gives an overview on the formation, structure, and function of elastic fibers and their fate over the human lifespan in health and disease.<\/jats:p>","DOI":"10.1111\/febs.15899","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T04:15:55Z","timestamp":1619324155000},"page":"3704-3730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":138,"title":["Elastic fibers: formation, function, and fate during aging and disease"],"prefix":"10.1111","volume":"289","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1180-0201","authenticated-orcid":false,"given":"Christian E. H.","family":"Schmelzer","sequence":"first","affiliation":[{"name":"Fraunhofer Institute for Microstructure of Materials and Systems IMWS  Halle (Saale) Germany"},{"name":"Institute of Pharmacy Faculty of Natural Sciences I Martin Luther University Halle\u2010Wittenberg  Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6035-4906","authenticated-orcid":false,"given":"Laurent","family":"Duca","sequence":"additional","affiliation":[{"name":"UMR CNRS 7369 MEDyC SFR CAP\u2010Sante Universit\u00e9 de Reims Champagne\u2010Ardenne  France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0369-8114(01)00147-X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/28.2.739"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15776"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20101320"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033560"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1995.1177"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2013.9"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.9.4916"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.05.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2018.07.016"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.2.1096"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.05.003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209256200"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00512-0"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(98)90106-8"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.121.1.201"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-7364-4-1-43"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-0491(79)90277-3"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1092"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)54095-3"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-36002-2_4"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.95411"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-36002-2_4"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2006.08.258"},{"key":"e_1_2_10_26_1","first-page":"696","article-title":"Human elastin gene: new evidence for localization to the long arm of chromosome 7","volume":"48","author":"Fazio MJ","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2019.06.010"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00006587"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14929"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-16555-9_8"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.16.5680"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12476591"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-2558(08)60201-5"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.327940"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.3.2.107"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/2.5.399"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0934-8832(11)80207-6"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)68942-2"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)61645-X"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.23007"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.6b00564"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801205115"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83613-X"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.68.3.411"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041160304"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-173X(84)80022-9"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3180149"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12337639"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.3.1.64"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/191710a0"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591577106400310"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12530093"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00449940"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90004-2"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(77)90372-4"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.30.1.59"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181132a9d"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2019.10.002"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(00)00098-6"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.130021"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.124.5.855"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2010.10.003"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.49"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.112.7.1093"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117930"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409029200"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706335105"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1401697111"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.06.061"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0237"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210611200"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.3.2205"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi971036f"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2018.07.016"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.003954"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00325-0"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm4011529"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(79)91608-5"},{"key":"e_1_2_10_79_1","first-page":"51","article-title":"General discussion.1. Hydroxylation of the VGVPG in ovine elastin","volume":"192","author":"Sandberg LB","year":"1995","journal-title":"Ciba F Symp"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2016.05.013"},{"key":"e_1_2_10_81_1","first-page":"185","article-title":"The 67 kDa spliced variant of beta\u2010galactosidase serves as a reusable protective chaperone for tropoelastin","volume":"192","author":"Hinek A","year":"1995","journal-title":"Ciba Found Symp"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.11.6319"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.419929"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14836"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1995.1321"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2018.06.010"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2006.10.002"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0610092"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20546"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(01)00262-X"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.00092.x"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2010.10.003"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1701877114"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2006.09.008"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M212715200"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.03.060"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008209909029104"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M507309200"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm7013153"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.31.21719"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.5.1700-1709.2006"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908268106"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.03.009"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.02.003"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2019.11.003"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-019-02404-x"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20180050"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc1404"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1297"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210144200"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201801860RR"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.5.996S"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00835a021"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00835a022"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1360045"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1462"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)81581-5"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/1971297a0"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008200009067665"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1080\/00021369.1991.10870592"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)82207-4"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(05)70013-9"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/31.7.1221"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.53.070184.003441"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-0491(82)90515-6"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008208009152122"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.019364"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20050368"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01330-06"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215779110"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2017.11.014"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.018960"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/209399b0"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2008.01.007"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1139\/o79-169"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00268874"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00190142"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008208509152400"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1998.274.6.L940"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(95)00149-A"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00123008"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.25.14899"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2012.11.004"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(92)90132-Z"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115204"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00383-5"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12012"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091140404"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90224-4"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.1168"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19970815)38:4<428::AID-JEMT10>3.0.CO;2-L"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-7206(79)90002-5"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(98)90126-3"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008200902855925"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2580533.x"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi060289i"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.9b00414"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014280108"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111615108"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-9093-0_28"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)42239-4"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/246461a0"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2014.03.008"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.30.17778"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1850611"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.004322"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-014-1075-9"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)42239-4"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)42348-X"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-9093-0_26"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.01.014"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2213"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.2367660"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.01.038"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2001.1022"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1981.360200611"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.11.022"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60055-8"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01557a016"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1974.360130404"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi034837t"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023422925910"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023474909980"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja010363e"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360320206"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2004.12.014"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310948200"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/30522"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(98)00098-3"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt336"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.3109\/01902148.2010.489143"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200949"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2002.1620"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-012-9467-3"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609505200"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.20029"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:GLYC.0000014082.99675.2f"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.017525"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2004.12.022"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15702"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.518381"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2012.12.004"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2101"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2009.02.010"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1517096113"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2003.10.003"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)50671-2"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.41.2.S36"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(98)00284-6"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60961-8"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(99)00113-9"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.08.014"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.4.810"},{"key":"e_1_2_10_214_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02196213"},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.01.250"},{"key":"e_1_2_10_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/0141-8130(83)90041-7"},{"key":"e_1_2_10_217_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411617200"},{"key":"e_1_2_10_218_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm7010104"},{"key":"e_1_2_10_219_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21472-0"},{"key":"e_1_2_10_220_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.4.2126"},{"key":"e_1_2_10_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2020.129544"},{"key":"e_1_2_10_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)89530-1"},{"key":"e_1_2_10_223_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.18.12189"},{"key":"e_1_2_10_224_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07616.x"},{"key":"e_1_2_10_225_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.65.2.137"},{"key":"e_1_2_10_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2011.10.006"},{"key":"e_1_2_10_227_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0508"},{"key":"e_1_2_10_228_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep35666"},{"key":"e_1_2_10_229_1","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0490"},{"key":"e_1_2_10_230_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-020-00755-z"},{"key":"e_1_2_10_231_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2978-6"},{"key":"e_1_2_10_232_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304432"},{"key":"e_1_2_10_233_1","doi-asserted-by":"publisher","DOI":"10.1159\/000159084"},{"key":"e_1_2_10_234_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6477com"},{"key":"e_1_2_10_235_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006550503612"},{"key":"e_1_2_10_236_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2004.22228.x"},{"key":"e_1_2_10_237_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20884"},{"key":"e_1_2_10_238_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.239"},{"key":"e_1_2_10_239_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23296"},{"key":"e_1_2_10_240_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051004"},{"key":"e_1_2_10_241_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199805000-00007"},{"key":"e_1_2_10_242_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/1.6.479"},{"key":"e_1_2_10_243_1","doi-asserted-by":"publisher","DOI":"10.1002\/psc.1277"},{"key":"e_1_2_10_244_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00032"},{"key":"e_1_2_10_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.11.022"},{"key":"e_1_2_10_246_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01613"},{"key":"e_1_2_10_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(06)79005-6"},{"key":"e_1_2_10_248_1","first-page":"45","article-title":"Effects of synthesized elastin peptides on human leukocytes","volume":"37","author":"Hauck M","year":"1995","journal-title":"Biochem Mol Biol Int"},{"key":"e_1_2_10_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(97)00042-9"},{"key":"e_1_2_10_250_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.1.1.461"},{"key":"e_1_2_10_251_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-001-0608-z"},{"key":"e_1_2_10_252_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.030171"},{"key":"e_1_2_10_253_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2010.00559.x"},{"key":"e_1_2_10_254_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.181"},{"key":"e_1_2_10_255_1","doi-asserted-by":"publisher","DOI":"10.1086\/341035"},{"key":"e_1_2_10_256_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2000.01703.x"},{"key":"e_1_2_10_257_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0903074"},{"key":"e_1_2_10_258_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8401-y"},{"key":"e_1_2_10_259_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706585"},{"key":"e_1_2_10_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2018.05.020"},{"key":"e_1_2_10_261_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2018.12.009"},{"key":"e_1_2_10_262_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.12.008"},{"key":"e_1_2_10_263_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00196"},{"key":"e_1_2_10_264_1","doi-asserted-by":"publisher","DOI":"10.1086\/504304"},{"key":"e_1_2_10_265_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.18.2113"},{"key":"e_1_2_10_266_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp148"},{"key":"e_1_2_10_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.07.001"},{"key":"e_1_2_10_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.09.013"},{"key":"e_1_2_10_269_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.180"},{"key":"e_1_2_10_270_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21462"},{"key":"e_1_2_10_271_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700047"},{"key":"e_1_2_10_272_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/352724"},{"key":"e_1_2_10_273_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.00919.x"},{"key":"e_1_2_10_274_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2003.00018.x"},{"key":"e_1_2_10_275_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2014.04.007"},{"key":"e_1_2_10_276_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1349"},{"key":"e_1_2_10_277_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.2010.956615"},{"key":"e_1_2_10_278_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.8.835"},{"key":"e_1_2_10_279_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61345-2"},{"key":"e_1_2_10_280_1","doi-asserted-by":"publisher","DOI":"10.1086\/425231"},{"key":"e_1_2_10_281_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22105"},{"key":"e_1_2_10_282_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.07.020"},{"key":"e_1_2_10_283_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.01.005"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.15899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.15899","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.15899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T08:55:47Z","timestamp":1692867347000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.15899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,10]]},"references-count":282,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/febs.15899"],"URL":"https:\/\/doi.org\/10.1111\/febs.15899","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,10]]},"assertion":[{"value":"2021-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}