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While T cells are broadly considered to be a component of the antigen\u2010specific adaptive immune response, certain T\u2010cell subsets display innate\u2010like effector characteristics whereas others perform immunosuppressive functions. These functionally diverse T\u2010cell populations preferentially arise at different stages of ontogeny and are tailored to the immunological priorities of the organism over time. Many differences in early life versus adult T\u2010cell phenotypes can be attributed to the cell\u2010intrinsic properties of the distinct progenitors that seed the thymus throughout development. It is becoming clear that Lin28, an evolutionarily conserved, heterochronic RNA\u2010binding protein that is differentially expressed among early life and adult hematopoietic progenitor cells, plays a substantial role in influencing early T\u2010cell development and function. Here, we discuss the mechanisms by which Lin28 shapes the T\u2010cell landscape to protect the developing fetus and newborn. Manipulation of the Lin28 gene regulatory network is being considered as one means of improving hematopoietic stem cell transplant outcomes; as such, understanding the impact of Lin28 on T\u2010cell function is of clinical relevance.<\/jats:p>","DOI":"10.1111\/febs.16045","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T21:29:56Z","timestamp":1622669396000},"page":"4416-4429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Developing the right tools for the job: Lin28 regulation of early life T\u2010cell development and function"],"prefix":"10.1111","volume":"289","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6246-3383","authenticated-orcid":false,"given":"Mengqi","family":"Dong","sequence":"first","affiliation":[{"name":"Immunology\u2010Oncology Unit Maisonneuve\u2010Rosemont Hospital Research Center  Montr\u00e9al QC Canada"},{"name":"D\u00e9partement de microbiologie, 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