{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:32:31Z","timestamp":1789565551118,"version":"build-2803163510"},"reference-count":185,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01NS088367"],"award-info":[{"award-number":["R01NS088367"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01NS092662"],"award-info":[{"award-number":["R01NS092662"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32CA06395"],"award-info":[{"award-number":["T32CA06395"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>JC polyomavirus (JCPyV), a ubiquitous human pathogen, causes several devastating brain diseases in immune\u2010compromised individuals. The most notable of these JCPyV\u2010associated CNS diseases is the frequently fatal demyelinating brain disease progressive multifocal leukoencephalopathy (PML). PML, an AIDS\u2010defining disease in the pre\u2010cART epoch, has emerged as a life\u2010threatening complication in patients receiving immunomodulatory agents for autoimmune and inflammatory disorders and treatment for certain hematological malignancies. Among the rapidly expanding list of PML\u2010associated biologics, natalizumab (Tysabri\u00ae) has the highest incidence and is an ominous sequela for multiple sclerosis (MS) patients who otherwise benefit from dramatic reductions in relapses using this immunomodulatory agent. Drug withdrawal, the only therapeutic option for PML, is often complicated by a high\u2010mortality cerebral inflammatory reaction. No anti\u2010JCPyV agents are available. Lack of a tractable animal model of polyomavirus\u2010induced central nervous system (CNS) disease is an acknowledged bottleneck to elucidating PML pathogenesis, immunological mechanisms that control JCPyV, <jats:italic>in\u2009vivo<\/jats:italic> evaluation of agents that inhibit polyomavirus replication in tissue culture, and uncovering early events that presage JCPyV\u2010associated neuropathology. The natural virus\u2013host mouse polyomavirus (MuPyV) model has recently been developed to explore mechanisms of polyomavirus\u2010associated CNS disease. In this review, we will cover the benefits of using the MuPyV model to answer fundamental questions about innate and adaptive immune control of JCPyV, the impact of immunomodulation on JCPyV pathogenesis, and how this MuPyV CNS infection model will help improve criteria for identifying patients at risk for JCPyV\u2010associated CNS diseases before the development of irreversible lesions.<\/jats:p>","DOI":"10.1111\/febs.16083","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T11:46:19Z","timestamp":1624103179000},"page":"5744-5761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Understanding polyomavirus CNS disease \u2013 a perspective from mouse models"],"prefix":"10.1111","volume":"289","author":[{"given":"Katelyn N.","family":"Ayers","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Penn State College of Medicine  Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah N.","family":"Carey","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Penn State College of Medicine  Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-2841","authenticated-orcid":false,"given":"Aron E.","family":"Lukacher","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Penn State College of Medicine  Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005574"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-83-20376"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(86)90056-5"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2992"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv155"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.66.1.238-245.2000"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.21.10290-10299.2001"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.12.9918-9923.1998"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00009-09"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg439"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00379-19"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008371"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01144-08"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02131-17"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703879114"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206273"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12110"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.09.009"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/152692480401400207"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d3303"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/373579"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280701469178"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000201"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlw050"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-001-0714-6"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/81.1.93"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-1-78"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170407"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.187666"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000235"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.2007.3.2.259"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285615615257"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe020157"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20858"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe058122"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03221-13"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.20.9687-9695.2001"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.023184-0"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-019-00753-y"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24148"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.10.7004-7012.1996"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.5.1.49"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1086\/653823"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198802043180507"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2017.01.006"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2020.02.007"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-186999"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.05.033"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182478d4b"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2011.524925"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2016.03.005"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.78.s2.03"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.70.7.4457-4465.1996"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.18.9526-9532.2002"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209681"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00527-10"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01160"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.11.6638"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.2.776-781.1989"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.29.3.990-996.1979"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(84)90172-7"},{"key":"e_1_2_12_63_1","first-page":"455","article-title":"Induction of brain tumors by a newly isolated JC virus (Tokyo\u20101 strain)","volume":"116","author":"Nagashima K","year":"1984","journal-title":"Am J Pathol"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203849"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206559"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0450"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230108"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318180f0d5"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.3.1361-1366.2005"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.08.007"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/63.7.750"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02231-17"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064313"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.03.020"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1972"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76629"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc946"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.1124"},{"key":"e_1_2_12_79_1","first-page":"359","article-title":"Paralysis in nude mice caused by polyomavirus\u2010induced vertebral tumors","volume":"105","author":"Harper JS","year":"1983","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2010.00247.x"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-64-1-57"},{"key":"e_1_2_12_82_1","first-page":"243","article-title":"Variations in polyoma virus genotype in relation to tumor induction in mice. Characterization of wild type strains with widely differing tumor profiles","volume":"127","author":"Dawe CJ","year":"1987","journal-title":"Am J Pathol"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.1.335-341.1991"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.1.342-349.1991"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9455"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.5.1683"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.12.10079-10085.1999"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.19.9657-9663.2002"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02038-19"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030179"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/br.25.1.18-31.1961"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05031-11"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24192"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.61056"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.04.003"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00105-18"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904267"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphereDirect.00494-17"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.5537"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2018.01.002"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02506-10"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.4.1724"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.5.595"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1993.1472"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-013-0222-6"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab1720"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30040-1"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.2.253"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.02.018"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.09.004"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103492"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.778-809.2001"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8009221"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1999.4670"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.3109\/10799899909036638"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8197455"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120231"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1086\/520518"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2007.11.002"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00903-16"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.10.012"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01571-06"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00761-11"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00199-16"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24192"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25608"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.063"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22753"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02064"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02692"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186966"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-019-00744-z"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.20906.1"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.08.008"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00374"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0427-y"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abb1817"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-019-00601-0"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.134258"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003650"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00159"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00617"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006318"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900093"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abb5590"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1362-5"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11638-3"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2017.62"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007365"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.11.056"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.231486598"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.945"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0860-3"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02290-10"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300582"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803557"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600207"},{"key":"e_1_2_12_158_1","first-page":"e01132","article-title":"Differential expression of immune checkpoint molecules on CD8 + T cells specific for immunodominant and subdominant herpes simplex virus 1 epitopes","volume":"94","author":"Carroll KL","year":"2019","journal-title":"J Virol"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31825a313c"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1815039"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00783"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.12.8056-8063.1994"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.68.7.4700-4704.1994"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172815"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175194"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174182"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.10.009"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.069"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01436"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.06.001"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abb6852"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24153"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803009"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.2.403"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.2.1113"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.9.5827"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12754"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0766"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00812-13"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.80863-0"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.06.012"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir198"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir256"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000368"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab1720"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac8691"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.16083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.16083","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.16083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:45:00Z","timestamp":1692675900000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.16083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,2]]},"references-count":185,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/febs.16083"],"URL":"https:\/\/doi.org\/10.1111\/febs.16083","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,2]]},"assertion":[{"value":"2021-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}