{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:40:20Z","timestamp":1792215620903,"version":"4.4.0"},"reference-count":69,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LU466\/16\u20102"],"award-info":[{"award-number":["LU466\/16\u20102"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>\n                    ADP\u2010ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in stress responses elicited, for example, by DNA damage and viral infection and is involved in intra\u2010 and extracellular signaling, chromatin and transcriptional regulation, protein biosynthesis, and cell death. ADP\u2010ribosylation is catalyzed by ADP\u2010ribosyltransferases (ARTs), which transfer ADP\u2010ribose from NAD\n                    <jats:sup>+<\/jats:sup>\n                    onto substrates. The modification, which occurs as mono\u2010 or poly\u2010ADP\u2010ribosylation, is reversible due to the action of different ADP\u2010ribosylhydrolases. Importantly, inhibitors of ARTs are approved or are being developed for clinical use. Moreover, ADP\u2010ribosylhydrolases are being assessed as therapeutic targets, foremost as antiviral drugs and for oncological indications. Due to the development of novel reagents and major technological advances that allow the study of ADP\u2010ribosylation in unprecedented detail, an increasing number of cellular processes and pathways are being identified that are regulated by ADP\u2010ribosylation. In addition, characterization of biochemical and structural aspects of the ARTs and their catalytic activities have expanded our understanding of this protein family. This increased knowledge requires that a common nomenclature be used to describe the relevant enzymes. Therefore, in this viewpoint, we propose an updated and broadly supported nomenclature for mammalian ARTs that will facilitate future discussions when addressing the biochemistry and biology of ADP\u2010ribosylation. This is combined with a brief description of the main functions of mammalian ARTs to illustrate the increasing diversity of mono\u2010 and poly\u2010ADP\u2010ribose mediated cellular processes.\n                  <\/jats:p>","DOI":"10.1111\/febs.16142","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T03:52:15Z","timestamp":1627530735000},"page":"7399-7410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":309,"title":["ADP\u2010ribosyltransferases, an update on function and nomenclature"],"prefix":"10.1111","volume":"289","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-8709","authenticated-orcid":false,"given":"Bernhard","family":"L\u00fcscher","sequence":"first","affiliation":[{"name":"Institute of Biochemistry and Molecular Biology RWTH Aachen University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9446-3756","authenticated-orcid":false,"given":"Ivan","family":"Ahel","sequence":"additional","affiliation":[{"name":"Sir William Dunn School of Pathology University of Oxford  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Altmeyer","sequence":"additional","affiliation":[{"name":"Department of Molecular Mechanisms of Disease University of Zurich  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Ashworth","sequence":"additional","affiliation":[{"name":"UCSF Helen Diller Family Comprehensive Cancer Center  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry Faculty of Medicine University of Debrecen  Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Chang","sequence":"additional","affiliation":[{"name":"ARase Therapeutics  Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Chemical Physiology and Biochemistry Oregon Health and Science University  Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Corda","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences National Research Council  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Dantzer","sequence":"additional","affiliation":[{"name":"CNRS, BSC\u2010UMR7242  Illkirch France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Daugherty","sequence":"additional","affiliation":[{"name":"Division of Biological Sciences University of California San Diego  La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted M.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valina L.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Deindl","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology Uppsala University  Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony R.","family":"Fehr","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences The University of Kansas  Lawrence KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla L. 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