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One gene found to be genetically altered in the X\u2010linked intellectual disability disorder Claes\u2010Jensen syndrome is\n                    <jats:italic>KDM5C<\/jats:italic>\n                    , which encodes a histone demethylase that regulates transcription by altering chromatin. While the genetic link between\n                    <jats:italic>KDM5C<\/jats:italic>\n                    and cognitive (dys)function is clear, how KDM5C functions to control transcriptional programs within neurons to impact their growth and activity remains the subject of ongoing research. Here, we review our current knowledge of Claes\u2010Jensen syndrome and discuss important new data using model organisms that have revealed the importance of KDM5C in regulating aspects of neuronal development and function. Continued research into the molecular and cellular activities regulated by KDM5C is expected to provide critical etiological insights into Claes\u2010Jensen syndrome and highlight potential targets for developing therapies to improve the quality of life of those affected.\n                  <\/jats:p>","DOI":"10.1111\/febs.16204","type":"journal-article","created":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T17:10:01Z","timestamp":1631985001000},"page":"7776-7787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Molecular and cellular events linking variants in the histone demethylase KDM5C to the intellectual disability disorder Claes\u2010Jensen syndrome"],"prefix":"10.1111","volume":"289","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5922-7291","authenticated-orcid":false,"given":"Hayden A. M.","family":"Hatch","sequence":"first","affiliation":[{"name":"Dominick P. 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