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Herein, we describe a role for C\/EBP\u03b2 as a regulator of skeletal muscle stem cell function. In particular, C\/EBP\u03b2 is expressed in muscle stem cells in healthy muscle where it inhibits myogenic differentiation. Downregulation of C\/EBP\u03b2 expression at the protein and transcriptional level allows for differentiation. Persistence of C\/EBP\u03b2 promotes stem cell self\u2010renewal and C\/EBP\u03b2 expression is required for mitotic quiescence in this cell population. As a critical regulator of skeletal muscle homeostasis, C\/EBP\u03b2 expression is stimulated in pathological conditions such as cancer cachexia, which perturbs muscle regeneration and promotes myofiber atrophy in the context of systemic inflammation. C\/EBP\u03b2 is also an important regulator of cytokine expression and immune response genes, a mechanism by which it can influence muscle stem cell function. In this viewpoint, we describe a role for C\/EBP\u03b2 in muscle stem cells and propose a functional intersection between C\/EBP\u03b2 and NF\u2010kB action in the regulation of cancer cachexia.<\/jats:p>","DOI":"10.1111\/febs.16307","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T05:57:54Z","timestamp":1638424674000},"page":"6518-6530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["From quiescence to repair: C\/EBP\u03b2 as a regulator of muscle stem cell function in health and disease"],"prefix":"10.1111","volume":"289","author":[{"given":"Hamood","family":"AlSudais","sequence":"first","affiliation":[{"name":"Graduate Program in Cellular and Molecular Medicine Faculty of Medicine University of Ottawa  Canada"},{"name":"Department of Clinical Laboratory Sciences College of Applied Medical Sciences King Saud University  Saudi 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