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Growing evidence supports the involvement of the fibroblast growth factor receptor (FGFR) axis in several cancers, including gynecological. However, for cervical cancer, the molecular mechanisms that underpin the disease remain poorly understood, including the role of FGFR signaling. The aim of this study was to investigate FGF(R) signaling in cervical cancer through bioinformatic analysis of cell line and patient data and through detailed expression profiling, manipulation of the FGFR axis, and downstream phenotypic analysis in cell lines (HeLa, SiHa, and CaSki). Expression (protein and mRNA) analysis demonstrated that FGFR1b\/c, FGFR2b\/c, FGFR4, FGF2, FGF4, and FGF7 were expressed in all three lines. Interestingly, FGFR1 and 2 localized to the nucleus, supporting that nuclear FGFRs could act as transcription factors. Importantly, 2D and 3D cell cultures demonstrated that FGFR activation can facilitate cell functions correlated with invasive disease. Collectively, this study supports an association between FGFR signaling and cervical cancer progression, laying the foundations for the development of therapeutic approaches targeting FGFR in this disease.<\/jats:p>","DOI":"10.1111\/febs.16331","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T13:52:55Z","timestamp":1640353975000},"page":"3440-3456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["FGF signalling facilitates cervical cancer progression"],"prefix":"10.1111","volume":"289","author":[{"given":"Hiba\u2010Tun\u2010Noor Afshan","family":"Mahmood","sequence":"first","affiliation":[{"name":"School of Life Sciences Pharmacy and Chemistry Kingston University  Kingston upon Thames UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Tomas Bort","sequence":"additional","affiliation":[{"name":"Centre for Tumour Biology, Barts Cancer Institute 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