{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:31:26Z","timestamp":1784853086561,"version":"3.55.0"},"reference-count":250,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"am","delay-in-days":345,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS095166"],"award-info":[{"award-number":["NS095166"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS103036"],"award-info":[{"award-number":["NS103036"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS110008"],"award-info":[{"award-number":["NS110008"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS116076"],"award-info":[{"award-number":["NS116076"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["AZ180127"],"award-info":[{"award-number":["AZ180127"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FEBS Journal"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>Ischaemic neurovascular stroke represents a leading cause of death in the developed world. Preclinical and human epidemiological evidence implicates the corticotropin\u2010releasing factor (CRF) family of neuropeptides as mediators of acute neurovascular injury pathology. Preclinical investigations of the role of CRF, CRF receptors and CRF\u2010dependent activation of the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis have pointed toward a tissue\u2010specific and temporal relationship between activation of these pathways and physiological outcomes. Based on the literature, the major phases of ischaemic stroke aetiology may be separated into an acute phase in which CRF and anti\u2010inflammatory stress signalling are beneficial and a chronic phase in which these contribute to neural degeneration, toxicity and apoptotic signalling. Significant gaps in knowledge remain regarding the pathway, temporality and systemic impact of CRF signalling and stress biology in neurovascular injury progression. Heterogeneity among experimental designs poses a challenge to defining the apparent reciprocal relationship between neurological injury and stress metabolism. Despite these challenges, it is our opinion that the elucidated temporality may be best matched with an antibody against CRF with a half\u2010life of days to weeks as opposed to minutes to hours as with small\u2010molecule CRF receptor antagonists. This state\u2010of\u2010the\u2010art review will take a multipronged approach to explore the expected potential benefit of a CRF antibody by modulating CRF and corticotropin\u2010releasing factor receptor 1 signalling, glucocorticoids and autonomic nervous system activity. Additionally, this review compares the modulation of CRF and HPA axis activity in neuropsychiatric diseases and their counterpart outcomes post\u2010stroke and assess lessons learned from antibody therapies in neurodegenerative diseases.<\/jats:p>","DOI":"10.1111\/febs.16380","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T18:20:44Z","timestamp":1643826044000},"page":"1986-2010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Role of CRF and the hypothalamic\u2010pituitary\u2010adrenal axis in stroke: revisiting temporal considerations and targeting a new generation of therapeutics"],"prefix":"10.1111","volume":"290","author":[{"given":"Daniel A.","family":"Lichlyter","sequence":"first","affiliation":[{"name":"Department of Anesthesiology University of Florida College of Medicine Center for Translational Research in Neurodegenerative Disease University of Florida  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary A.","family":"Krumm","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Florida College of Medicine Center for Translational Research in Neurodegenerative Disease University of Florida  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd A.","family":"Golde","sequence":"additional","affiliation":[{"name":"Department of Neuroscience University of Florida College of Medicine Center for Translational Research in Neurodegenerative Disease University of Florida  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3771-5109","authenticated-orcid":false,"given":"Sylvain","family":"Dor\u00e9","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Florida College of Medicine Center for Translational Research in Neurodegenerative Disease University of Florida  Gainesville FL USA"},{"name":"Department of Neuroscience University of Florida College of Medicine Center for Translational Research in Neurodegenerative Disease University of Florida  Gainesville FL USA"},{"name":"Departments of Neurology, Psychiatry, Pharmaceutics McKnight Brain Institute University of Florida College of Medicine  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"KochanekKD XuJ&AriasEMortality in the United States. Products \u2010 Data Briefs \u2010 Number 395 \u2010 December 2020. Hyattsville MD: U.S. Department of Health & Human Services 2019."},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.09.038"},{"key":"e_1_2_14_4_1","first-page":"95","article-title":"Monoclonal antibody as an emerging therapy for acute ischemic stroke","volume":"12","author":"Woods D","year":"2020","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113518"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.141"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00042.2017"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2006.8.4\/ssmith"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c150015"},{"key":"e_1_2_14_10_1","volume-title":"Physiology, adrenocorticotropic hormone (ACTH)","author":"Allen MJ","year":"2018"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2005.10.003"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197405022901808"},{"key":"e_1_2_14_13_1","first-page":"63","article-title":"ACTH: cellular peptide hormone synthesis and secretory pathways","volume":"50","author":"Stevens A","year":"2010","journal-title":"Results Probl Cell Differ"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31828a6a01"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12090"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13217"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399815666191111152248"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2015.1067677"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.02.027"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(01)00722-5"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(93)90184-L"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.11.014"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03327435"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2004.04.024"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.1999.10.2.117"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2005.03.003"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.120"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2019.07.003"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2019.00043"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2010.03.007"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.19.8777"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-803592-4.00062-6"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.12.7665"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1995.1004"},{"key":"e_1_2_14_35_1","first-page":"R744","article-title":"CRF activates autonomic nervous system and reduces natural killer cytotoxicity","volume":"255","author":"Irwin M","year":"1988","journal-title":"Am J Physiol"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.7.1072"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.131.3.1047"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1600001"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0314-y"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.85"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2701-18.2019"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-021-00973-x"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91485-0"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91310-W"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2004.17.8.863694"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.130.1.152"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-128-3-1329"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.02.002"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4491"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K09E-075"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.12.034"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2010.009347"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.2004.04216.x"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0194"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2003926"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5173-06.2007"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2005.03.004"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5611-10.2011"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04209.x"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2013.806907"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1154"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16009"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26331"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000189996.71237.f7"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01594.x"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(03)00211-9"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-3042.2001.00712.x"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204387"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00372-5"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00150.x"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0143-04.2004"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2007.00356.x"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.29.20597"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.12.078"},{"key":"e_1_2_14_75_1","first-page":"105","article-title":"Corticotropin\u2010releasing factor increases protein kinase C activity by elevating membrane\u2010bound alpha and beta isoforms","volume":"37","author":"Kiang JG","year":"1994","journal-title":"Chin J Physiol"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/0922-4106(94)90164-3"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-008-8036-x"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2005.tb00043.x"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1916fje"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8344-z"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.00028"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394309-5.00006-7"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489241"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-49844-3_10"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502070102"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328226"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(03)00126-X"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01510.x"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300488"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184907"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.12.004"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06747.x"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109361"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152706777950684"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00099.2006"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.2004.04371.x"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2012.01.006"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2015.11.088"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2417-0"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-013-9340-9"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15030464"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.11.036"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.019312"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.12.007"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.5.833"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.12.1784"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.580929"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0779-7"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-996-0031-9"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000138023.60272.9e"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00948"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199901000-00010"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2016.07.001"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2015.10.010"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00064.x"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199509000-00019"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00032-8"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevNeurobiol.v10.i2.10"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb49922.x"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2013.00068"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01631.x"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.19.8382"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91382-X"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-12-04758.1998"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2011.04.014"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803216105"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02019-9"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2009.04.016"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2001.0395"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-02-00404.2002"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01207-3"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12050"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000086957.72078.D4"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2008.06.002"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2020.07.008"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.02.014"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2015.03.001"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.04.062"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2007.03.004"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02240-5"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2014.01.003"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.10.027"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1492-17.2017"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.07.031"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200110000-00009"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.01.033"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.06.021"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-005-2303-0"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.06.035"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.607705"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082428"},{"key":"e_1_2_14_152_1","first-page":"85","article-title":"Influence of the corticotropin releasing hormone (CRH) on the brain\u2010blood barrier permeability in cerebral ischemia in rats","volume":"53","author":"Hendryk S","year":"2002","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(86)90032-7"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.3171\/2011.8.JNS101637"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018114"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07812.x"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1404493111"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2007.10.008"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-3203"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008251426425"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01544.x"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-3042.2001.00687.x"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2016.07.003"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10010096"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-13"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0613875"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190430"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0190-z"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102224"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-24-09473.1997"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.16.9317"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505183322008"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.4.1212"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02243"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91535-9"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.9.6983"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-128-1-37"},{"key":"e_1_2_14_178_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-126-6-2876"},{"key":"e_1_2_14_179_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0409"},{"key":"e_1_2_14_180_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2010.02327.x"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314518"},{"key":"e_1_2_14_182_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90400.2008"},{"key":"e_1_2_14_183_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-7231-5"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1053\/jscd.2002.126688"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01334.x"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)05308-7"},{"key":"e_1_2_14_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.01.010"},{"key":"e_1_2_14_188_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000016967.76805.BF"},{"key":"e_1_2_14_189_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-7378-2-18"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143493"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.6.1105"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350908"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319713503487"},{"key":"e_1_2_14_194_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00592"},{"key":"e_1_2_14_195_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.2000.tb00117.x"},{"key":"e_1_2_14_196_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1210200110"},{"key":"e_1_2_14_197_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157982"},{"key":"e_1_2_14_198_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2009-0443"},{"key":"e_1_2_14_199_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122614"},{"key":"e_1_2_14_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2011.04.012"},{"key":"e_1_2_14_201_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9010035"},{"key":"e_1_2_14_202_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0242-18.2019"},{"key":"e_1_2_14_203_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1762-z"},{"key":"e_1_2_14_204_1","article-title":"Corticosteroids for acute ischaemic stroke","author":"Sandercock PA","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_205_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(19990915)33:4<304::AID-SYN7>3.0.CO;2-Z"},{"key":"e_1_2_14_206_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.218"},{"key":"e_1_2_14_207_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb49931.x"},{"key":"e_1_2_14_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300191"},{"key":"e_1_2_14_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90595-0"},{"key":"e_1_2_14_210_1","doi-asserted-by":"publisher","DOI":"10.3389\/conf.fendo.2011.03.00004"},{"key":"e_1_2_14_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.04.017"},{"key":"e_1_2_14_212_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.11.11.1401"},{"key":"e_1_2_14_213_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511320103"},{"key":"e_1_2_14_214_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.7937"},{"key":"e_1_2_14_215_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2013.00156"},{"key":"e_1_2_14_216_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2143-18.2018"},{"key":"e_1_2_14_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.04.027"},{"key":"e_1_2_14_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(97)00099-1"},{"key":"e_1_2_14_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.09.040"},{"key":"e_1_2_14_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.07.010"},{"key":"e_1_2_14_221_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2013-1095"},{"key":"e_1_2_14_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90132-5"},{"key":"e_1_2_14_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00571-7"},{"key":"e_1_2_14_224_1","doi-asserted-by":"publisher","DOI":"10.2165\/11587790-000000000-00000"},{"key":"e_1_2_14_225_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2012.00091"},{"key":"e_1_2_14_226_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2017_86"},{"key":"e_1_2_14_227_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09183-0"},{"key":"e_1_2_14_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.12.017"},{"key":"e_1_2_14_229_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301328"},{"key":"e_1_2_14_230_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881111400650"},{"key":"e_1_2_14_231_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4556-2"},{"key":"e_1_2_14_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2010.02.011"},{"key":"e_1_2_14_233_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.94"},{"key":"e_1_2_14_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2016.09.004"},{"key":"e_1_2_14_235_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30085"},{"key":"e_1_2_14_236_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-129-1-446"},{"key":"e_1_2_14_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2017.01.004"},{"key":"e_1_2_14_238_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.160"},{"key":"e_1_2_14_239_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.08.010"},{"key":"e_1_2_14_240_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.004731"},{"key":"e_1_2_14_241_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728214.2020.1808621"},{"key":"e_1_2_14_242_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12213"},{"key":"e_1_2_14_243_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1110143"},{"key":"e_1_2_14_244_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aan6480"},{"key":"e_1_2_14_245_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-3515-3_7"},{"key":"e_1_2_14_246_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01139"},{"key":"e_1_2_14_247_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00032"},{"key":"e_1_2_14_248_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20199"},{"key":"e_1_2_14_249_1","doi-asserted-by":"publisher","DOI":"10.1159\/000126974"},{"key":"e_1_2_14_250_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1997.272.2.E312"},{"key":"e_1_2_14_251_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414176200"}],"container-title":["The FEBS Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.16380","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/febs.16380","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111\/febs.16380","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/febs.16380","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T12:32:27Z","timestamp":1692707547000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1111\/febs.16380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,22]]},"references-count":250,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/febs.16380"],"URL":"https:\/\/doi.org\/10.1111\/febs.16380","archive":["Portico"],"relation":{},"ISSN":["1742-464X","1742-4658"],"issn-type":[{"value":"1742-464X","type":"print"},{"value":"1742-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,22]]},"assertion":[{"value":"2021-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}