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Advances in structural biology techniques have contributed substantially to our current understanding of the life cycle of these small enveloped RNA viruses and led to deep insights into details of virus assembly, maturation and cell entry. In addition to large\u2010scale conformational changes and oligomeric rearrangements of envelope proteins during these processes, there is increasing evidence that smaller\u2010scale protein dynamics (referred to as virus \u201cbreathing\u201d) can confer extra flexibility to these viruses for the fine\u2010tuning of their interactions with the immune system and possibly with cellular factors they encounter in their complex ecological cycles in arthropod and vertebrate hosts. In this review, we discuss how work with tick\u2010borne encephalitis virus has extended our view on flavivirus breathing, leading to the identification of a novel mechanism of antibody\u2010mediated infection enhancement and demonstrating breathing intermediates of the envelope protein in the process of membrane fusion. 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